Phenotypic Characterization of Very Early-Onset Inflammatory Bowel Disease with Interleukin-10 Signaling Deficiency: Based on a Large Cohort Study
| Autor: | Yuhuan Wang, Jieru Shi, Junping Lu, Jie Wu, Wenhui Hu, Zifei Tang, Shijian Miao, Aijuan Xue, Kaiyue Peng, Ziqing Ye, Cuifang Zheng, Xiaowen Qian, Zhiheng Huang, Ying Zhou, Ying Huang, Hua Sun, Lin Wang |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Lymphoma B-Cell medicine.medical_treatment Hematopoietic stem cell transplantation Gastroenterology Inflammatory bowel disease Interleukin 10 receptor alpha subunit Cohort Studies 03 medical and health sciences 0302 clinical medicine immune system diseases Internal medicine medicine Humans Immunology and Allergy Receptors Interleukin-10 Age of Onset Child Genetic Association Studies business.industry Mortality rate Infant Newborn Infant Inflammatory Bowel Diseases Prognosis medicine.disease Rash Interleukin-10 Lymphoma Interleukin 10 Phenotype 030104 developmental biology Child Preschool Mutation Female 030211 gastroenterology & hepatology medicine.symptom business Rare disease |
| Zdroj: | Inflammatory Bowel Diseases. 25:756-766 |
| ISSN: | 1536-4844 1078-0998 |
| Popis: | BACKGROUND Interleukin-10 (IL10)/interleukin-10 receptor (IL10R) deficiency is a rare disease with life-threatening infantile-onset colitis. We sought to accurately phenotype this disorder based on a large cohort of patients with a proven defect of IL10 signaling and to clarify the effects of allogeneic hematopoietic stem cell transplantation (HSCT). METHODS We analyzed the phenotypes of our 61 patients and reviewed 78 other previously reported cases with identified mutations in the genes encoding IL10 or IL10R. We also compared the clinical features of patients with interleukin-10 receptor B (IL10RB), interleukin-10 receptor A (IL10RA), and IL10 mutations. The therapeutic effects of allogeneic HSCT were evaluated. RESULTS We found that the disease onset time was extremely early: 70.3% within 30 days postnatal and 94.9% within the first 6 months of life. In addition, 94.2% of patients typically presented with perianal lesions. Oral ulcers and skin rash were common extra-intestinal manifestations (33.8% and 51.8%, respectively). There was no statistically significant difference in disease onset time, perianal lesion involvement, or mortality rate among patients with IL10RB, IL10RA, or IL10 deficiency. However, the surgery rate was higher in patients with IL10RB mutations than in those with IL10 or IL10RA mutations (P < 0.05). Compared with those with IL10RA deficiency, a higher percentage (32%, 9 of 28) of patients with IL10RB mutations developed B-cell lymphoma (P < 0.01). Compared with other regions, a higher percentage (98.7%) of IL10RA mutations was detected among patients in East Asia countries (P < 0.01), with hot-spot mutation sites of c.C301T and c.G537A. Allogeneic HSCT is efficacious but has a high mortality rate (17.5%, 7 of 40). CONCLUSIONS Our study expands the current knowledge on the genotype-correlated phenotypes with a defect of IL10 signaling. B-cell lymphoma was more frequent than would be expected in patients with IL10RB mutations. There may be a unique genetic architecture among Eastern Asia compared with other populations. Although allogeneic HSCT represents a causal therapeutic approach for IL10-and IL10R-deficient patients, a word of caution is warranted. |
| Databáze: | OpenAIRE |
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