Under the Radar: Epidemiology of Plasmodium ovale in the Democratic Republic of the Congo
| Autor: | Melchior Kashamuka Mwandagalirwa, Nicholas F Brazeau, Corinna Keeler, Jonathan J. Juliano, Antoinette Tshefu, Steven R. Meshnick, Cedar L Mitchell |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Plasmodium ovale 030231 tropical medicine Prevalence Disease cluster digestive system Major Articles and Brief Reports 03 medical and health sciences 0302 clinical medicine stomatognathic system parasitic diseases Epidemiology medicine Humans Immunology and Allergy Risk factor biology business.industry digestive oral and skin physiology Plasmodium falciparum medicine.disease biology.organism_classification Malaria 030104 developmental biology Infectious Diseases Democratic Republic of the Congo business Ovale malaria Demography |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiaa478 |
| Popis: | Background Plasmodium ovale is an understudied malaria species prevalent throughout much of sub-Saharan Africa. Little is known about the distribution of ovale malaria and risk factors for infection in areas of high malaria endemicity. Methods Using the 2013 Democratic Republic of the Congo (DRC) Demographic and Health Survey, we conducted a risk factor analysis for P. ovale infections. We evaluated geographic clustering of infections and speciated to P. ovale curtisi and P. ovale wallikeri through deep sequencing. Results Of 18 149 adults tested, we detected 143 prevalent P. ovale infections (prevalence estimate 0.8%; 95% confidence interval [CI], .59%–.98%). Prevalence ratios (PR) for significant risk factors were: male sex PR = 2.12 (95% CI, 1.38–3.26), coprevalent P. falciparum PR = 3.52 (95% CI, 2.06–5.99), and rural residence PR = 2.19 (95% CI, 1.31–3.66). P. ovale was broadly distributed throughout the DRC; an elevated cluster of infections was detected in the south-central region. Speciation revealed P. ovale curtisi and P. ovale wallikeri circulating throughout the country. Conclusions P. ovale persists broadly in the DRC, a high malaria burden country. For successful elimination of all malaria species, P. ovale needs to be on the radar of malaria control programs. |
| Databáze: | OpenAIRE |
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