Young adult patients with squamous cell carcinoma of the tongue strongly express p16 without human papillomavirus infection
| Autor: | Tadashi Yoshino, Kana Ikegami, Yorihisa Orita, Tomoyasu Tachibana, Takuma Makino, Kazunori Nishizaki, Kentaro Miki, Toshihiro Ito, Yuka Gion, Yasuharu Sato, Munechika Tsumura, Hidenori Marunaka, Naoki Akisada, Yusuke Akagi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Young Adult 03 medical and health sciences 0302 clinical medicine Japan Tongue Internal medicine medicine Humans Basal cell Young adult Human papillomavirus 030223 otorhinolaryngology Papillomaviridae Cyclin-Dependent Kinase Inhibitor p16 Aged Retrospective Studies Aged 80 and over business.industry Incidence (epidemiology) Cancer General Medicine P16 protein Middle Aged medicine.disease Tongue Neoplasms medicine.anatomical_structure Otorhinolaryngology Younger adults 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female business |
| Zdroj: | Acta Oto-Laryngologica. 139:80-84 |
| ISSN: | 1651-2251 0001-6489 |
| Popis: | Long-term smoking and drinking are known to contribute to the onset of tongue cancer (TC). However, the increasing incidence of TC in younger adults has been suggested to be associated with other factors.The present study investigated the relationship between TC and human papillomavirus (HPV) infection.Clinical records and surgically resected specimens from 86 patients (40-years-old, n = 12; ≥40-years-old, n = 74) with TC were analyzed. Strong nuclear and cytoplasmic p16 staining was considered positive. HPV DNA (high-risk subtypes: 16, 18, 31, 33, 35, 52b, and 58; low-risk subtypes: 6 and 11) was detected using consensus primer-mediated polymerase chain reaction.Strong p16 expression was observed in 10 (11.6%) patients. HPV DNA was detected in 9 (10.5%) patients (high-risk subtypes, n = 2; low-risk subtypes, n = 7). Strong p16 expression was observed more frequently among younger adults than among older adults (33.3% vs. 8.1%; p = .045). p16 staining did not correlate with the detection of HPV DNA (correlation coefficient, 0.113; p = .300).In TC, p16 expression was not associated with HPV infection, suggesting that it may be caused by a different mechanism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |