Distinct effect of Chrysanthemum indicum Linné extracts on isoproterenol-induced growth of human hepatocellular carcinoma cells
| Autor: | Aihua Yuan, Xinqiu Li, Jianmin Bian, Shanyong Yi, Zongfang Li, Kaiwang Shi, Shukui Wang |
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| Rok vydání: | 2009 |
| Předmět: |
MAPK/ERK pathway
Cancer Research medicine.medical_specialty Carcinoma Hepatocellular Time Factors Chrysanthemum Blotting Western Inflammation Antineoplastic Agents Pharmacology Internal medicine Cell Line Tumor medicine Humans Chrysanthemum indicum Cell Proliferation Oncogene biology Dose-Response Relationship Drug Cell growth Plant Extracts Liver Neoplasms Isoproterenol General Medicine biology.organism_classification Flow Cytometry humanities Gene Expression Regulation Neoplastic Endocrinology Oncology Cell culture Apoptosis Cancer cell medicine.symptom Drug Screening Assays Antitumor |
| Zdroj: | Oncology reports. 22(6) |
| ISSN: | 1791-2431 |
| Popis: | Chrysanthemum indicum Linne (Asteraceae) is a common Chinese herbal medicine that has been traditionally used for the treatment of inflammation, hypertension and neoplastic diseases in China. However, the mechanism that account for the inhibitory activity of Chrysanthemum indicum Linne against cancer cells is poorly understood. We investigated the effect of Chrysanthemum indicum Linne extracts (CILE) on isoproterenol (ISO) induced growth of human hepatocellar carcinoma (HCC) cells in correlation with the intracellular activity of MAPK/ERK1/2. We found that CILE was effective in attenuating the mitogenic effect of ISO on both HepG2 and MHCC97H cells. The inhibitory effect of CILE was mediated by inhibiting the ISO-induced activation of MAPK/ERK1/2 via beta2-AR in tumor cells. Our findings will be helpful in understanding the anticancer mechanism of CILE. |
| Databáze: | OpenAIRE |
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