Association of physical activity and sedentary time with structural brain networks-The Maastricht Study
| Autor: | Nicolaas C. Schaper, Annemarie Koster, Miranda T. Schram, Jacobus F.A. Jansen, Laura W. M. Vergoossen, J.J.A. de Jong, Walter H. Backes, Coen D.A. Stehouwer, Hans H.C.M. Savelberg |
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| Přispěvatelé: | RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Beeldvorming, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: DA BV Klinisch Fysicus (9), MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3), Interne Geneeskunde, MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), RS: CAPHRI - R2 - Creating Value-Based Health Care, RS: Carim - V02 Hypertension and target organ damage, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Nutrition and Movement Sciences, Sociale Geneeskunde, RS: CAPHRI - R4 - Health Inequities and Societal Participation |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Aging medicine.medical_specialty Physical activity EXERCISE MOTOR CONTROL TISSUE SEGMENTATION White matter 03 medical and health sciences Elderly population-based cohort 0302 clinical medicine AGE Internal medicine Basal ganglia Linear regression medicine Humans 030212 general & internal medicine OLDER-ADULTS Aged business.industry ABNORMALITIES Structural connectivity Brain Motor control White Matter Sedentary behavior medicine.anatomical_structure Blood pressure Cardiovascular Diseases Elderly population–based cohort Cardiology Original Article Female Geriatrics and Gerontology Primary motor cortex business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Geroscience, 43(1), 239-252. Springer International Publishing GeroScience |
| ISSN: | 2509-2715 |
| Popis: | We assessed whether objectively measured low- and high-intensity physical activity (LPA and HPA) and sedentary time (ST) were associated with white matter connectivity, both throughout the whole brain and in brain regions involved in motor function. In the large population-based Maastricht Study (n = 1715, age 59.6 ± 8.1 (mean ± standard deviation) years, and 48% women), the amounts of LPA, HPA, and ST were objectively measured during 7 days by an activPAL accelerometer. In addition, using 3T structural and diffusion MRI, we calculated whole brain node degree and node degree of the basal ganglia and primary motor cortex. Multivariable linear regression analysis was performed, and we report standardized regression coefficients (stβ) adjusted for age, sex, education level, wake time, diabetes status, BMI, office systolic blood pressure, antihypertensive medication, total-cholesterol-to-HDL-cholesterol ratio, lipid-modifying medication, alcohol use, smoking status, and history of cardiovascular disease. Lower HPA was associated with lower whole brain node degree after full adjustment (stβ [95%CI] = − 0.062 [− 0.101, − 0.013]; p = 0.014), whereas lower LPA (stβ [95%CI] = − 0.013 [− 0.061, 0.034]; p = 0.580) and higher ST (stβ [95%CI] = − 0.030 [− 0.081, 0.021]; p = 0.250) was not. In addition, lower HPA was associated with lower node degree of the basal ganglia after full adjustment (stβ [95%CI] = − 0.070 [− 0.121, − 0.018]; p = 0.009). Objectively measured lower HPA, but not lower LPA and higher ST, was associated with lower whole brain node degree and node degree in specific brain regions highly specialized in motor function. Further research is needed to establish whether more HPA may preserve structural brain connectivity. |
| Databáze: | OpenAIRE |
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