Effects of Endocrine-Disrupting Chemicals and Epigenetic Modifications in Ovarian Cancer: A Review
| Autor: | Deepali Garg, Ratika Samtani, Noopur Sharma |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Ovarian Neoplasms
0301 basic medicine Obstetrics and Gynecology Cancer Endocrine Disruptors Biology Malignancy medicine.disease Bioinformatics Epigenesis Genetic 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis DNA methylation medicine Humans Endocrine system Environmental Pollutants Female Epigenetics Ovarian cancer Carcinogen Hormone |
| Zdroj: | Reproductive Sciences. 25:7-18 |
| ISSN: | 1933-7205 1933-7191 |
| DOI: | 10.1177/1933719117711261 |
| Popis: | Ovarian cancer (OC) is a relatively fatal female reproductive malignancy. Since the underlying causes are uncertain, it brings us to believe that both genetic and external factors contribute toward development of this lethal disorder. Exposure to endocrine-disrupting chemicals (EDCs) in the form of occupational usage of pesticides, fungicides, herbicides, plasticizers, cosmetics, and so on is potentially carcinogenic and their ability to cause epigenetic modifications has led us to hypothesize that they may play a catalytic role in OC progression. In response to synthetic chemicals, animal models have demonstrated disturbances in the development of ovaries and steroid hormonal levels but in humans, more research is required. The present review is an attempt to address the impact of EDCs on the hormonal system and gene methylation levels that may lead to malfunctioning of the ovaries which may consequently develop in the form of cancer. It can be concluded that endocrine disruptors do have a potential carcinogenicity and their high proportions in human body may cause epigenetic modifications, prompting ovarian surface epithelium to grow in an abnormal manner. |
| Databáze: | OpenAIRE |
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