Loading Rate of Exogenous and Autoantigenic Determinants on Major Histocompatibility Complex Class II Mediates Resistance to Multiple Sclerosis
| Autor: | N. A. Vorobieva, A N Boyko, Ivan Kiselev, V. D. Knorre, Olga O. Favorova, A. E. Mamedov, E. N. Khurs, M. Yu. Zakharova, Alexey A. Belogurov, Natalia Baulina, Olga Kulakova, Alexander G. Gabibov |
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| Rok vydání: | 2019 |
| Předmět: |
Male
musculoskeletal diseases Multiple Sclerosis Biophysics Endogeny Biology Autoantigens Biochemistry Genetic analysis law.invention 03 medical and health sciences immune system diseases law medicine Humans Allele skin and connective tissue diseases 030304 developmental biology 0303 health sciences Major Histocompatibility Complex Class II Multiple sclerosis 030302 biochemistry & molecular biology Myelin Basic Protein General Chemistry General Medicine Middle Aged medicine.disease Molecular biology Myelin basic protein biology.protein Loading rate Recombinant DNA Female Peptides HLA-DRB1 Chains |
| Zdroj: | Doklady Biochemistry and Biophysics. 485:115-118 |
| ISSN: | 1608-3091 1607-6729 |
| Popis: | Genetic analysis of thousands of patients with multiple sclerosis (MS) and healthy Russian donors showed that the carriage of groups of HLA-DRB1*15 and HLA-DRB1*03 alleles is associated with the risk of MS, whereas the carriage of groups of HLA-DRB1*01 and HLA-DRB1*11 alleles is protective. Recombinant HLA-DRB1*01:01 with a high affinity can recognize the fragments of myelin basic protein (MBP), one of the autoantigens in MS. However, the comparison of the kinetic parameters of the load of MBP and viral HA peptides on HLA-DRB1*01:01, which is catalyzed by HLA-DM, showed a significantly lower rate of exchange of CLIP for MBP peptides. We assume that the observed protective properties of the group of HLA-DRB1*01 alleles may be directly associated with the ability of HLA-DRB1*01:01 to kinetically distinguish peptides of exogenous and endogenous nature. |
| Databáze: | OpenAIRE |
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