Pathologic findings in reduction mammoplasty specimens: a surrogate for the population prevalence of breast cancer and high-risk lesions
| Autor: | Judy Garber, Clara Li, Kevin S. Hughes, Suzanne B. Coopey, Francisco Acevedo, Amy S. Colwell, Danielle Braun, Regina Barzilay, Adam Yala, Tari A. King, Barbara L. Smith, Anthony J. Guidi, Curtis L. Cetrulo, Rong Tang, V. Diego Armengol, Zhengyi Deng |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Mammaplasty Population Mammoplasty Breast Neoplasms Asymptomatic Reduction Mammoplasty Cohort Studies 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Atypia Prevalence Humans Breast education Aged Aged 80 and over education.field_of_study Incidental Findings business.industry Age Factors Ductal carcinoma Middle Aged medicine.disease 030104 developmental biology Oncology Massachusetts 030220 oncology & carcinogenesis Female medicine.symptom business Precancerous Conditions |
| Zdroj: | Other repository |
| Popis: | © 2018, Springer Science+Business Media, LLC, part of Springer Nature. Purpose: Mammoplasty removes random samples of breast tissue from asymptomatic women providing a unique method for evaluating background prevalence of breast pathology in normal population. Our goal was to identify the rate of atypical breast lesions and cancers in women of various ages in the largest mammoplasty cohort reported to date. Methods: We analyzed pathologic reports from patients undergoing bilateral mammoplasty, using natural language processing algorithm, verified by human review. Patients with a prior history of breast cancer or atypia were excluded. Results: A total of 4775 patients were deemed eligible. Median age was 40 (range 13–86) and was higher in patients with any incidental finding compared to patients with normal reports (52 vs. 39 years, p = 0.0001). Pathological findings were detected in 7.06% (337) of procedures. Benign high-risk lesions were found in 299 patients (6.26%). Invasive carcinoma and ductal carcinoma in situ were detected in 15 (0.31%) and 23 (0.48%) patients, respectively. The rate of atypias and cancers increased with age. Conclusion: The overall rate of abnormal findings in asymptomatic patients undergoing mammoplasty was 7.06%, increasing with age. As these results are based on random sample of breast tissue, they likely underestimate the prevalence of abnormal findings in asymptomatic women. |
| Databáze: | OpenAIRE |
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