The structure of bovine brain myelin proteolipid and its organization in myelin
| Autor: | Mohammed Samiullah, Richard A. Laursen, Marjorie B. Lees |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Proteolipid protein 1
Protein Conformation Proteolipids Biology Structure-Activity Relationship Myelin Protein structure medicine Animals Amino Acid Sequence Cysteine Myelin Proteolipid Protein Lipid bilayer Myelin proteolipid Myelin Sheath Multidisciplinary Bilayer Water Myelin basic protein Myelin proteolipid protein medicine.anatomical_structure Solubility nervous system Biochemistry biology.protein Biophysics Cattle Myelin Proteins Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 81:2912-2916 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.81.9.2912 |
| Popis: | A model, based on amino acid sequence data, is proposed for the organization of the myelin proteolipid in myelin membrane. The model has three distinctive features: three trans-membrane segments that traverse the lipid bilayer, two cis-membrane domains that enter and exit the same side of the membrane, and a highly charged segment resembling myelin basic protein on the cytoplasmic side of the membrane. It is proposed that the cis-membrane domain(s) can promote the formation and stabilization of the multilamellar myelin structure by hydrophobic interaction with the apposite bilayer across the extracellular space. |
| Databáze: | OpenAIRE |
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