Therapeutic effects of andiroba (Carapa guianensis Aubl) oil, compared to low power laser, on oral mucositis in children underwent chemotherapy: A clinical study
| Autor: | e.Fabrício Mesquita Tuji, Ana Márcia Viana Wanzeler, Gabriel Henrique Soares Cavalcante, Elsa Maria da Silva Barros, Rita de Cássia Matos Carneiro, Artur dos Santos Soares |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Visual analogue scale medicine.medical_treatment Analgesic ved/biology.organism_classification_rank.species Antineoplastic Agents 03 medical and health sciences 0302 clinical medicine Double-Blind Method Statistical significance Internal medicine Drug Discovery Mucositis Humans Plant Oils Medicine Low-Level Light Therapy Meliaceae Child Pain Measurement 030304 developmental biology Pharmacology Stomatitis 0303 health sciences Chemotherapy Carapa guianensis business.industry ved/biology Therapeutic effect medicine.disease Clinical trial Treatment Outcome Leukemia Myelomonocytic Juvenile Child Preschool 030220 oncology & carcinogenesis Female business |
| Zdroj: | Journal of Ethnopharmacology. 264:113365 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/j.jep.2020.113365 |
| Popis: | Ethno-pharmacological relevance The Carapa guianensis Aubl, popularly known as andiroba, is a large tree of the Meliaceae family, commonly found in the Amazon region. The oil extracted from its seeds is recognized in traditional medicine and has high anti-inflammatory and analgesic potential, which are the basic prerequisites for a therapeutic agent that can be used in the treatment of oral mucositis (OM). Moreover, the aforementioned oil has antimicrobial, antiallergic, and parasiticidal actions and is effective in the management of cutaneous and muscular dysfunctions. Aim of the study To evaluate the therapeutic effects of andiroba gel (Carapa guianensis Aubl) on the symptomatology and evolution of OM in children with leukemia who underwent chemotherapy and to compare it to the effects of low power laser. Materials and methods This randomized, double-blind clinical trial involved 60 patients of both genders with leukemia, with age ranging from six to twelve years. The patients were divided into two study groups: the andiroba group (n = 30) and the laser group (n = 30). The level of pain experienced by the patients was assessed using the Wong-Baker visual analog scale and the degree of severity of OM was assessed using a table, recommended by the World Health Organization, that depicts the degrees of severity of OM. The data obtained were analyzed using the Mann-Whitney test, with statistical significance indicated by a P value less than or equal to 0.05. Results A statistically significant reduction in the degree of OM was observed on the fourth, fifth, and sixth days and in the pain scores on the second, third, and fourth days in the andiroba group after the manifestation of OM, compared to the laser group. Conclusions The use of andiroba oil effectively reduced the severity of OM and relieved pain, which resulted in a decrease in the severity of signs and symptoms in the patients in the andiroba group, compared to the laser group. |
| Databáze: | OpenAIRE |
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