Pregnancy outcome in women exposed to antiepileptic drugs: teratogenic role of maternal epilepsy and its pharmacologic treatment
| Autor: | Arianna Dilaghi, Matteo Cassina, Guido Mannaioni, Marco De Santis, Alessandra Pistelli, Elena Di Gianantonio, Elena Cesari, Maurizio Clementi |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Offspring Toxicology Pharmacological treatment Epilepsy Young Adult Pregnancy Medicine Humans antiepileptic drugs Prospective Studies Young adult Prospective cohort study teratology business.industry Infant Newborn Pregnancy Outcome Abnormalities Drug-Induced Middle Aged medicine.disease Teratology Settore MED/40 - GINECOLOGIA E OSTETRICIA Italy Anesthesia Observational study Anticonvulsants Female business |
| Zdroj: | Reproductive toxicology (Elmsford, N.Y.). 39 |
| ISSN: | 1873-1708 |
| Popis: | Infants born to epileptic women treated with antiepileptic drugs (AEDs) have an increased risk of major congenital malformations (MCMs). In order to determine the role of maternal epilepsy we conducted a prospective cohort study on three cohorts of pregnant women: (i) 385 epileptic women treated with AEDs, (ii) 310 non-epileptic women treated with AEDs, (iii) 867 healthy women not exposed to AEDs (control group). The rate of MCMs in the epileptic group (7.7%) was not statistically higher than in the non-epileptic one (3.9%) (p=0.068). The rate in the first group was higher compared to the control group (p=0.001), while the rate in the second one was not (p=0.534). Our data confirm that AEDs therapy is the main cause of the increased risk of malformations in the offspring of epileptic women; however a teratogenic role of the maternal epilepsy itself cannot be excluded. |
| Databáze: | OpenAIRE |
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