Nonhuman Primate Optogenetics: Recent Advances and Future Directions
| Autor: | Adriana Galván, Michael C. Schmid, Leah Acker, Shay Ohayon, Ken-ichi Inoue, William R. Stauffer, Yasmine El-Shamayleh |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell specific Primates Opsin General Neuroscience Symposium and Mini-Symposium Brain Human brain Biology Optogenetics Neuronal pathway Nonhuman primate 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Neurology medicine Animals Humans Neuroscience 030217 neurology & neurosurgery Brain function Clearance |
| Zdroj: | The Journal of Neuroscience |
| ISSN: | 0270-6474 |
| DOI: | 10.1523/jneurosci.1839-17.2017 |
| Popis: | Optogenetics is the use of genetically coded, light-gated ion channels or pumps (opsins) for millisecond resolution control of neural activity. By targeting opsin expression to specific cell types and neuronal pathways, optogenetics can expand our understanding of the neural basis of normal and pathological behavior. To maximize the potential of optogenetics to study human cognition and behavior, optogenetics should be applied to the study of nonhuman primates (NHPs). The homology between NHPs and humans makes these animals the best experimental model for understanding human brain function and dysfunction. Moreover, for genetic tools to have translational promise, their use must be demonstrated effectively in large, wild-type animals such as Rhesus macaques. Here, we review recent advances in primate optogenetics. We highlight the technical hurdles that have been cleared, challenges that remain, and summarize how optogenetic experiments are expanding our understanding of primate brain function. |
| Databáze: | OpenAIRE |
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