Reduced Brainstem Volume After Mild Traumatic Brain Injury
| Autor: | Seo Jung Yun, Won Sang Cho, Han Gil Seo, Seung Hong Choi, Min Gu Kang, Seung Hak Lee, Eunkyung Kim, Roh Eul Yoo, Hyun Haeng Lee, Byung Mo Oh |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 030506 rehabilitation medicine.medical_specialty Traumatic Brain Injury Traumatic brain injury Concussion Physical Therapy Sports Therapy and Rehabilitation Neuroimaging Verbal learning White matter 03 medical and health sciences Young Adult 0302 clinical medicine Cerebrospinal fluid Internal medicine Original Research Articles Surveys and Questionnaires medicine Humans Cognitive Dysfunction Brain Concussion Retrospective Studies business.industry Rehabilitation Organ Size Middle Aged medicine.disease Magnetic Resonance Imaging Traumatic injury medicine.anatomical_structure Brain size Cardiology ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Female 0305 other medical science business Neurocognitive 030217 neurology & neurosurgery Brain Stem |
| Zdroj: | American Journal of Physical Medicine & Rehabilitation |
| ISSN: | 1537-7385 0894-9115 |
| Popis: | Supplemental digital content is available in the text. Objective The aims of this study were to investigate changes in regional brain volume after concussion (mild traumatic brain injury) and to examine the relationship between change in brain volume and cognitive deficits. Design Twenty-eight patients with mild traumatic brain injury and 27 age-matched controls were included in this study. Magnetic resonance imaging (3 T) data were obtained from the participants. Structural brain volume changes were examined using tensor-based morphometry, which identifies regional structural differences in the whole brain, including cerebrospinal fluid, gray matter, and white matter. Volume contraction and expansion were compared between groups using a two-sample t test. The association between time post-injury or neurocognitive function and volumetric changes was examined using regression analysis. Results Individuals with mild traumatic brain injury exhibited volume reduction in the brainstem, including the pontine reticular formation. Regional cerebral volume changes were not associated with time post-injury but were significantly associated with neurocognitive function, especially with executive card sorting test, forward digit span test, and performance on verbal learning test. The greater regional cerebral volume was associated with better cognitive performance after mild traumatic brain injury. Conclusion Decreased brainstem volume may indicate its vulnerability to traumatic injury, and cerebral volume in specific regions was positively associated with patients’ cognitive function after injury. |
| Databáze: | OpenAIRE |
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