Immunogenetic factors in HPV-associated cervical cancer: influence on disease progression
| Autor: | F. R. A. Stevens, M. F. Duggan-Keen, Philip A. Dyer, S. Davidson, Peter L. Stern, J. M. M. Walboomers, Robin D Hunter, P. J. Keating, P.J. Sinnott, P. J. F. Snijders |
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| Rok vydání: | 1996 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Immunology Uterine Cervical Neoplasms Human leukocyte antigen Biology Pathogenesis Internal medicine Genotype Genetics medicine Immunogenetics Humans Allele Papillomaviridae Aged Cervical cancer Aged 80 and over Histocompatibility Testing Papillomavirus Infections Middle Aged medicine.disease biology.organism_classification Tumor Virus Infections In utero Disease Progression Female Viral disease Follow-Up Studies |
| Zdroj: | European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 23(4) |
| ISSN: | 0960-7420 |
| Popis: | No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west England and controls (corrected P values). HLA-DRB1*1501/DQB1*0602 was non-significantly increased, particularly among patients with HPV16-positive tumours. HLA-B7-positive patients had a significantly poorer clinical outcome than HLA-B7-negative patients. A significant component of the genotypic effect is down-regulation of HLA-B7 expression by the tumour cells. |
| Databáze: | OpenAIRE |
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