Chemotherapy-induced nausea and vomiting from oral chemotherapy for childhood acute lymphoblastic leukaemia: feasibility study
| Autor: | Rikesh Kumar Patel, Priya Patel, Lillian Sung, Sue Zupanec, Araby Sivananthan, Edric Paw Cho Sing, L. Lee Dupuis, Sarah Alexander, Anja Kovacevic, Ashlee Vennettilli |
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| Rok vydání: | 2019 |
| Předmět: |
Pediatrics
medicine.medical_specialty Electronic data capture Adolescent Nausea Vomiting Psychological intervention Medicine (miscellaneous) Antineoplastic Agents 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Maintenance therapy Medicine Humans 030212 general & internal medicine Prospective Studies Child Oncology (nursing) business.industry General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma Patient recruitment Medical–Surgical Nursing Cross-Sectional Studies Child Preschool Feasibility Studies Antiemetics Observational study medicine.symptom business Chemotherapy-induced nausea and vomiting |
| Zdroj: | BMJ supportivepalliative care. 12(e5) |
| ISSN: | 2045-4368 |
| Popis: | ObjectiveTo evaluate the feasibility of a large prospective trial aimed at improving chemotherapy-induced nausea and vomiting (CINV) control in paediatric patients undergoing oral chemotherapy during acute lymphoblastic leukaemia (ALL) maintenance therapy.MethodsEnglish-speaking children, 4.0–17.99 years old and undergoing ALL maintenance treatment with an English-speaking guardian, were eligible to participate in this observational, serial, cross-sectional feasibility study. Data were collected from participants over one to three 7-day periods during months 2–3, 5–6 and 11–12 of ALL maintenance treatment. A future trial was considered feasible if the mean time to enrol 10 patients in each of three data collection periods was ≤1 year with ≥80% of patients returning evaluable data. CINV control was described as a secondary endpoint.ResultsTwenty-nine of 31 consenting patients (median age: 6.5 years, IQR: 5.1–9.2) completed the study: 10 in months 2–3, 10 in months 5–6 and 9 in months 11–12. The total time to recruit 29 patients was 1.2 years. In each of the three data collections periods, 72% of the patients provided evaluable data. Complete CINV control was reported in 6/21 (29%) evaluable study periods.ConclusionsA future trial to evaluate interventions to improve CINV control in patients with ALL undergoing oral maintenance chemotherapy as designed in this study is not feasible. An electronic data capture method and deferring patient recruitment until the mid-maintenance to late-maintenance phase should be considered in the design of a future trial. |
| Databáze: | OpenAIRE |
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