Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K‑10 Clay Explored as Protection–Deprotection Chemistry

Autor:	Ravichandran Ganesan, Vaithiyanathan Vadivel, Ezhumalai Vellikannu, Vishnu Kannaiyan, Thirumailavan Vijayakumar
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	lcsh:Chemistry chemistry.chemical_compound chemistry lcsh:QD1-999 General Chemical Engineering Isatin Hydrazine Molecule Dinitrophenyl General Chemistry Medicinal chemistry Article Adduct
Zdroj:	ACS Omega, Vol 4, Iss 5, Pp 9563-9568 (2019) ACS Omega
ISSN:	2470-1343
Popis:	An interesting synthetic transformation of protection-deprotection chemistry in an isatin molecule is achieved. Morita-Baylis-Hillman (MBH) adduct formation used as protection of the C-3 position in the isatin molecule is reported. C-C bond cleavage in the MBH adduct of isatin with the help of phenylhydrazine and C=N bond cleavage in the phenylhydrazone derivative of isatin with the help of K10 clay are studied systematically and reported as deprotection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18df83f405e9cf0df623d72e3431fe1a https://doaj.org/article/e26970109c254ec9b923ff84740d321b Zobrazit plný text záznamu