Molecular basis for the selective toxicity of amphotericin B for yeast and filipin for animal cells
| Autor: | Gerald Medoff, George S. Kobayashi, David Schlessinger, Janina Kotler-Brajtburg, H. D. Price |
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| Rok vydání: | 1974 |
| Předmět: |
Antifungal Agents
Erythrocytes Polyenes Saccharomyces cerevisiae Biology Filipin Hemolysis chemistry.chemical_compound Amphotericin B medicine polycyclic compounds Animals Humans Pharmacology (medical) Drug Interactions Pharmacology Ergosterol Cell growth Cholesterol Articles Sterol Yeast Anti-Bacterial Agents Sterols Infectious Diseases chemistry Biochemistry Toxicity lipids (amino acids peptides and proteins) medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy. 5(4) |
| ISSN: | 0066-4804 |
| Popis: | Among the polyene antibiotics, many, like filipin, cannot be used clinically because they are toxic; amphotericin B, however, is useful in therapy of human fungal infections because it is less toxic. Both the toxicity of filipin and the therapeutic value of amphotericin B can be rationalized at the cellular and molecular level by the following observations: (i) these polyene antibiotics showed differential effects on cells; filipin was more potent in lysing human red blood cells, whereas amphotericin B was more potent in inhibiting yeast cell growth; and (ii) the effects of filipin were more efficiently inhibited by added cholesterol, the major membrane sterol in human cells, whereas the effects of amphotericin B were more efficiently inhibited by ergosterol, the major membrane sterol in yeast. The simplest inference is that the toxicity and effectiveness of polyenes are determined by their relative avidities for the predominant sterol in cell membranes. |
| Databáze: | OpenAIRE |
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