Simultaneous PML/RARα and AML1/ETO expression with t(15;17) at onset and relapse with only t(8;21) in an acute promyelocytic leukemia patient
| Autor: | Ana Inés Landoni, Hugo Giordano, Enrique Bódega, Rossana Bonomi, Marı́a del Rosario Uriarte, Robert E. Gallagher, Marı́a del Pilar Moreno |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Acute promyelocytic leukemia Cancer Research medicine.medical_specialty Oncogene Proteins Fusion Chromosomes Human Pair 21 Chromosomal translocation T-15 Biology Translocation Genetic Fusion gene RUNX1 Translocation Partner 1 Protein Leukemia Promyelocytic Acute Recurrence Genetics medicine Humans RNA Neoplasm Molecular Biology Chromosomes Human Pair 15 Reverse Transcriptase Polymerase Chain Reaction Cytogenetics Karyotype medicine.disease Neoplasm Proteins Gene Expression Regulation Neoplastic Karyotyping Core Binding Factor Alpha 2 Subunit Immunology Cancer research K562 Cells Clone (B-cell biology) Chromosomes Human Pair 17 Chromosomes Human Pair 8 Transcription Factors K562 cells |
| Zdroj: | Cancer Genetics and Cytogenetics. 123:41-43 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/s0165-4608(00)00297-1 |
| Popis: | We report a patient with acute promyelocytic leukemia with the common translocation (15;17) and PML-RARAalpha fusion gene. In relapse, blasts showed typical FAB M2 morphologic features, and the karyotype was 45,X, -Y,t(8;21). A reexamination of the leukemic cells at diagnosis revealed that an AML1-ETO fusion gene was also present at that time without cytogenetic evidence of t(8;21). In relapse, only t(8;21) was detected. Two different clones were identified by cytogenetic standard techniques. The association of two common translocations supervening in the same time in the same cells could not be established. |
| Databáze: | OpenAIRE |
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