Effect of GHB-use and GHB-induced comas on dorsolateral prefrontal cortex functioning in humans

Autor: Yvon D.A.T. de Vries, Guido van Wingen, Nikki Polderman, Wim van den Brink, Filipa Raposo Pereira, Minni T. B. McMaster
Přispěvatelé: Graduate School, Amsterdam Neuroscience - Brain Imaging, Adult Psychiatry
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Hydroxybutyrates
Audiology
Neuropsychological Tests
lcsh:RC346-429
Functional connectivity
0302 clinical medicine
Medicine
Drug addiction
Coma
Brain Mapping
medicine.diagnostic_test
Regular Article
Magnetic Resonance Imaging
3. Good health
medicine.anatomical_structure
Memory
Short-Term
Neurology
lcsh:R858-859.7
Animal studies
medicine.symptom
Adult
medicine.medical_specialty
Adolescent
Cognitive Neuroscience
Prefrontal Cortex
lcsh:Computer applications to medicine. Medical informatics
Gyrus Cinguli
03 medical and health sciences
Young Adult
Humans
Radiology
Nuclear Medicine and imaging
Adverse effect
lcsh:Neurology. Diseases of the nervous system
Gamma-Hydroxybutyric acid (GHB) abuse
Memory Disorders
business.industry
Working memory
GHB-induced coma
Medial frontal gyrus
030227 psychiatry
Dorsolateral prefrontal cortex
Functional magnetic resonance imaging (fMRI)
Neurology (clinical)
business
Functional magnetic resonance imaging
030217 neurology & neurosurgery
Zdroj: NeuroImage : Clinical
NeuroImage. Clinical, 20, 923-930. Elsevier BV
NeuroImage: Clinical, Vol 20, Iss, Pp 923-930 (2018)
ISSN: 2213-1582
Popis: Background Gamma-hydroxybutyric acid (GHB) is a recreational drug associated with increasing numbers of GHB-dependent patients and emergency attendances often related to GHB-induced comas. Working memory (WM) deficits have been reported in association with GHB use, and animal studies have shown that GHB induces oxidative stress in vulnerable WM-related brain areas such as the dorsolateral prefrontal cortex (DLPFC). However, the effects of chronic GHB use and multiple GHB-induced comas on WM-related brain function in humans remains unknown. Methods We recruited 27 GHB users with ≥4 GHB-induced comas (GHB-Coma), 27 GHB users who never experienced GHB-induced coma (GHB-NoComa), and 27 polydrug users who never used GHB (No-GHB). Participants performed an n-back WM task during functional magnetic resonance imaging (fMRI) to probe DLPFC functioning. Results The GHB-Coma group had lower premorbid IQ (p = .006) than the GHB-NoComa group despite comparable age and education level. There were also group differences in the use of other drugs than GHB. Therefore, all group comparisons were adjusted for IQ and drug use other than GHB. Compared with the GHB-NoComa and the No-GHB groups, the GHB-Coma group showed increased activity in the right DLPFC (pSVC = 0.028) and increased functional connectivity of the right DLPFC with a cluster comprising the left anterior cingulate and medial frontal gyrus (pFWE = 0.003). No significant fMRI differences were observed between the GHB-NoComa and No-GHB groups. Due to technical problems, no behavioural data were collected. Discussion These results suggest that multiple GHB-induced comas, but not GHB-use per se, are associated with alterations in WM-related brain function. Public awareness campaigns are required to minimize the potential adverse effects induced by GHB recreational use, and especially GHB-induced comas, even if no immediate side effects are experienced.
Highlights • It appears that not GHB use per se, but multiple GHB-induced comas are associated with an alteration of the working memory network in regular GHB-users. • A Multiple GHB-induced comas are associated with hyperactivation of the right dorsal-lateral pre-frontal cortex (DLPFC). • Multiple GHB-induced comas are associated with increased DLPFC functional connectivity with the left anterior cingulate and medial frontal gyrus.
Databáze: OpenAIRE
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