Reactivity of ferrous myoglobin at low pH

Autor:	Gm Giacometti, Eraldo Antonini, Paolo Ascenzi, Maurizio Brunori, Tg Traylor
Přispěvatelé:	Giacometti, Gm, Traylor, Tg, Ascenzi, Paolo, Brunori, M, Antonini, E.
Rok vydání:	1977
Předmět:	Carbon Monoxide Myoglobin Iron Kinetics Inorganic chemistry Whales Protonation Cell Biology Hydrogen-Ion Concentration Biochemistry Ferrous Reaction rate chemistry.chemical_compound chemistry Animals Reactivity (chemistry) Molecular Biology Heme Carbon monoxide
Zdroj:	Scopus-Elsevier
ISSN:	0021-9258
DOI:	10.1016/s0021-9258(17)40986-0
Popis:	The rates of reaction of myoglobin with carbon monoxide at low pH are reported. The pH versus rate profile of these kinetics resembles that found for heme model compounds, revealing an increase in combination rate at low pH. These facts suggest that CO binding by myoglobin changes from a mechanism of "direct ligant association" at pH 5 to a mechanism, similar to that proposed for heme model compounds, which assumes a tetracoordinated intermediate as a result of the protonation of the proximal imidazole.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ddc05788baa02cdfc21590581d139e https://doi.org/10.1016/s0021-9258(17)40986-0 Zobrazit plný text záznamu