Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases
| Autor: | Magnus Abrahamson, Poonam Ahuja-Jensen, Satpal Ahuja, María Sancho-Tello, Francisco Bosch-Morell, Siv Johnsen-Soriano, Francisco J. Romero, Theo van Veen |
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| Rok vydání: | 2007 |
| Předmět: |
Retinal degeneration
genetic structures Glutathione reductase medicine.disease_cause Retina chemistry.chemical_compound Mice Malondialdehyde medicine Animals chemistry.chemical_classification Cyclic Nucleotide Phosphodiesterases Type 6 Glutathione Peroxidase biology Phosphoric Diester Hydrolases General Neuroscience Glutathione peroxidase Retinal Degeneration Age Factors Gene Expression Regulation Developmental Retinal Glutathione medicine.disease Molecular biology eye diseases Mice Mutant Strains Oxidative Stress chemistry Biochemistry Animals Newborn biology.protein sense organs Oxidative stress NADP Peroxidase Peptide Hydrolases |
| Zdroj: | Neuroreport. 18(8) |
| ISSN: | 0959-4965 |
| Popis: | Malondialdehyde, reduced glutathione, glutathione peroxidase, glutathione reductase and cysteine protease cathepsins at postnatal (PN) days 2, 7, 14, 21 and 28 in controls (wt) and the retinal degeneration 1 (rd1) mouse model for retinitis pigmentosa retinas were measured to determine oxidative stress. In PN28 wt and PN2 rd1 retinas, elevated malondialdehyde and low glutathione peroxidase activity indicate higher oxidative load, despite higher reduced glutathione in PN2 rd1 retinas. This is due to physiological exposure to light and retinal vascular/neural restructuring, respectively. Compared with wt retinas, relatively high malondialdehyde at PN2 and cathepsin levels at PN14, 21 and 28 in rd1 retinas indicate that cells of the residual inner retina also contribute to the oxidative stress and retinal degeneration. |
| Databáze: | OpenAIRE |
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