Oxidative stress after a carbohydrate meal contributes to the deterioration of diastolic cardiac function in nonhypertensive insulin-treated patients with moderately well controlled type 2 diabetes
| Autor: | Antonio Ceriello, H. von Bibra, T. Schuster, M. St. John Sutton, T. Siegmund, Petra-Maria Schumm-Draeger |
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| Rok vydání: | 2013 |
| Předmět: |
Cardiac function curve
Adult Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Diastole Hemodynamics Type 2 diabetes medicine.disease_cause Biochemistry Endocrinology Internal medicine Diabetes mellitus Dietary Carbohydrates Medicine Humans Insulin Prospective Studies Aged Aged 80 and over business.industry Biochemistry (medical) Heart General Medicine Middle Aged medicine.disease Postprandial Period Oxidative Stress Rate pressure product Diabetes Mellitus Type 2 Female business Oxidative stress |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 45(6) |
| ISSN: | 1439-4286 |
| Popis: | The prevalence and prognostic importance of diastolic dysfunction in type 2 diabetes has only recently been appreciated. We tested the hypothesis that in insulin treated type 2 diabetes (D), carbohydrate consumption induces oxidative stress resulting in further impairment of diastolic function beyond structural myocardial stiffness. The effects of a pure carbohydrate breakfast (48 g) on oxidative stress and cardiac function were studied in the fasting and postmeal states in subjects without hypertension or overt cardiac disease (moderately well controlled D, n=21 and controls without D, n=20). Studied variables included systolic and early diastolic (E') myocardial velocities, traditional metabolic and hemodynamic parameters, serum nitrotyrosine, and sVCAM-1. In D compared to control subjects, the postmeal increase (∆) in glucose (1.44±2.78 vs. 0.11±0.72 mmol/l, p=0.04) and ∆nitrotyrosine (0.34±0.37 vs. -0.23±0.47 nM/l, p |
| Databáze: | OpenAIRE |
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