Eutectic Composition of a Chiral Mixture Containing a Racemic Compound
| Autor: | Ivan Santos, Rosario LoBrutto, Yaling Wang, Robert Wenslow |
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| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | Organic Process Research & Development. 9:670-676 |
| ISSN: | 1520-586X 1083-6160 |
| DOI: | 10.1021/op0501038 |
| Popis: | The enantioseparation process is of great interest to the pharmaceutical industry since more than 50% of the pharmaceutically active ingredients are known to be chiral and one enantiomer is usually preferred over the racemic mixture. Crystallization is widely used as the final step to reject the enantiomeric impurity from a mixture. Yet, a fundamental guidance on developing a purification procedure for systems forming racemic compounds (which account for more than 90% of all chiral systems) is not available. In this work, it is shown that the enantiomeric excess (ee) of the eutectic point is the key information needed to assess the feasibility of a crystallization process and to predict the purity and the yield of the product. In a dilute solution, the eutectic ee is determined solely by a eutectic constant (Keu), a new parameter introduced in this paper. Keu is defined as the ratio of the activity of the major enantiomer to that of the minor enantiomer. A eutectic constant equation was derived from the b... |
| Databáze: | OpenAIRE |
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