Neural biomarker of functional disability in major depressive disorder: A structural neuroimaging study
| Autor: | Yiru Fang, Chen Zhang, Lvchun Cui, Chengmei Yuan, Jijun Wang, Ruizhi Mao, Lena Palaniyappan, Tao Yang, Jun Chen, Guoqing Zhao, Chenglei Wang, Weiping Xia, Ru-Bai Zhou, Daihui Peng, Yong Wang, Jia Huang, Yousong Su, Jingjing Xu, Zuowei Wang, Fan Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Right parahippocampal gyrus
Adult Male Social Interaction Neuroimaging Major depressive disorder 03 medical and health sciences 0302 clinical medicine A longitudinal study Brain structure Medicine Humans In patient Gray Matter Biological Psychiatry Social functioning Pharmacology Depressive Disorder Major business.industry Social function Brain medicine.disease Magnetic Resonance Imaging 030227 psychiatry Functional disability Biomarker (medicine) Parahippocampal Gyrus Female business Biomarkers Clinical psychology |
| Zdroj: | Brain and Mind Institute Researchers' Publications |
| Popis: | Background: Most patients with the major depressive disorder (MDD) have varying degrees of impaired social functioning, and functional improvement often lags behind symptomatic improvement. However, it is still unclear if certain neurobiological factors underlie the deficits of social function in MDD. The aim of this study was to investigate the biomarkers of social function in MDD using structural magnetic resonance imaging (MRI). Methods: 3T anatomical MRI was obtained from 272 subjects including 46 high-functioning (high-SF, Sheehan Disability Scale (SDS) rating < 18) and 63 low-functioning (low-SF, SDS score ≥ 18) patients with MDD and 163 healthy controls (HC). Voxel-based morphometry (VBM) was employed to locate brain regions with grey matter (GM) volume differences in relation to social function in MDD. Regions showing GM differences in relation to social function at baseline were followed up longitudinally in a subset of 38 patients scanned after 12-week treatment. Results: Volume of right parahippocampal gyrus (rPHG) was significantly reduced in low-SF patients with MDD when compared to high-SF ones (FDR-corrected p < 0.05). Over 12 weeks of follow-up, though SF improved overall, the high and low-SF subgroups continued to differ in their SF, but had no progressive changes in PHG volume. Limitations: Limited functional assessment, high drop-out rate and median-based grouping method. Conclusions: Greater GM volume (GMV) of the rPHG may mark better social function in patients with MDD. |
| Databáze: | OpenAIRE |
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