Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives
| Autor: | Givanildo da Silva, Carlos A. M. Fraga, Tatiane L. Balliano, Roberto T. Sudo, Carla M. Leal, Mariano A. Pereira, Arthur Eugen Kümmerle, Eliezer J. Barreiro, Juliana M Raimundo, Carlos A. de Simone, Gisele Zapata-Sudo |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Models Molecular Pharmacology chemistry.chemical_classification Bicyclic molecule Molecular model Chemistry Stereochemistry Vasodilator Agents Organic Chemistry Hydrazones Hydrazone Aorta Thoracic Thiophenes General Medicine Crystallography X-Ray Chemical synthesis Pyrrole derivatives Rats Derivative (finance) Drug Discovery Benzene derivatives Animals Cardiovascular drug Rats Wistar |
| Zdroj: | European Journal of Medicinal Chemistry. 44:4004-4009 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/j.ejmech.2009.04.044 |
| Popis: | In this report we disclose the synthesis, vasodilatory activity, and identification of bioactive conformation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, structurally designed by bioisosteric replacements of previously described cardioactive compounds LASSBio-294 and its N-methyl derivative LASSBio-785. Some of these novel derivatives presented improved vasorelaxant properties, being new cardiovascular drug candidates. |
| Databáze: | OpenAIRE |
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