The Effectivity Analysis of Accumulation of Liposomal, Micellar, and Water-Soluble Forms of Diminazene in Cells and in Organs

Autor:	D. A. Zhemerichkin, S. Yu. Shchyogolev, K. P. Gabalov, Lev A. Dykman, D. V. Pristensky, A. A. Shcherbakov, D.N. Yermilov, S. A. Staroverov, V. A. Sidorkin
Rok vydání:	2006
Předmět:	Drug Erythrocytes media_common.quotation_subject Pharmaceutical Science Pharmacology Kidney Micelle Mice Diminazene medicine Animals Diminazene aceturate Tissue Distribution Lymphocytes Calcimycin Cells Cultured Micelles media_common Liposome Dose-Response Relationship Drug Chemistry Macrophages Water General Medicine Trypanocidal Agents Solutions Treatment Outcome Water soluble Liver Liposomes Cattle Injections Intraperitoneal medicine.drug
Zdroj:	Drug Delivery. 13:351-355
ISSN:	1521-0464 1071-7544
Popis:	The study was aimed at evaluating the effectiveness of liposomal, micellar, and water-soluble drug forms of diminazene for its localization in cells and selective accumulation at the sites of aggregation of pathogenic organisms. Pharmacological and dynamic properties of a new injection micellar diminazene preparation were experimentally determined. These properties were compared with the same parameters obtained for the water-soluble and liposomal diminazene aceturate drug forms. The drug forms studied may be arranged in the following order of decreasing effectiveness of accumulation of diminazene in red and white blood cells and in murine organs: liposome form, micellar form, and water-soluble form.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d348b619ada6d41ffe8ee8933c8e3f https://doi.org/10.1080/10717540500459084 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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