Antiinflammatory .beta.-arylamidoacrylic acids
| Autor: | Barrie M. Phillips, Harold E. Hartzler, Robert T. Buckler |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Anti-Inflammatory Agents
Coloring agents Stereoisomerism Carrageenan Medicinal chemistry Structure-Activity Relationship chemistry.chemical_compound Isomerism Drug Discovery medicine Phenylbutazone Animals Structure–activity relationship Coloring Agents Beta (finance) Pleurisy medicine.disease Amides Rats Acrylates chemistry Halogen Molecular Medicine medicine.drug |
| Zdroj: | Journal of Medicinal Chemistry. 18:509-513 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00239a015 |
| Popis: | A series of 34 beta-arylamidoacrylic acids was prepared and examined for antiinflammatory activity. These compounds are vinylogous carbamic acids, and several displayed activity equal to phenylbutazone in the rat pleural effusion model. Highest activity was associated with structures bearing halogen and cyano substituents. Amides were inactive. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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