Pharmacokinetic aspects of retinal drug delivery
| Autor: | Emma M. Heikkinen, Maxim Antopolsky, Arto Urtti, Tatu Lajunen, Eva M. del Amo, Elisa Toropainen, Madhushree Bhattacharya, Tiina Turunen, Mechthild Schmitt, Laura Pelkonen, Marika Ruponen, Anna-Kaisa Rimpelä, Dominique Richardson, Kati-Sisko Vellonen, Mika Reinisalo, Jaakko Itkonen, Astrid Subrizi, Otto K. Kari, Heidi Kidron, Eva Ramsay, Marco G. Casteleijn |
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| Přispěvatelé: | School of Pharmacy, Activities |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Drug medicine.medical_specialty media_common.quotation_subject Transport Angiogenesis Inhibitors Drug action Pharmacology Distribution Retina Vitreous 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Retinal Diseases Pharmacokinetics Sub-conjunctival medicine Animals Humans Distribution (pharmacology) Tissue Distribution Pharmacokinetic modeling Intensive care medicine media_common Suprachoroidal business.industry Choroid Sensory Systems eye diseases 3. Good health Review article Ophthalmology 030104 developmental biology medicine.anatomical_structure Tolerability Topical Intravitreal Injections Drug delivery 030221 ophthalmology & optometry Clearance sense organs business Intravitreal |
| Zdroj: | del Amo, E M, Rimpelä, A K, Heikkinen, E, Kari, O K, Ramsay, E, Lajunen, T, Schmitt, M, Pelkonen, L, Bhattacharya, M, Richardson, D, Subrizi, A, Turunen, T, Reinisalo, M, Itkonen, J, Toropainen, E, Casteleijn, M, Kidron, H, Antopolsky, M, Vellonen, K S, Ruponen, M & Urtti, A 2017, ' Pharmacokinetic aspects of retinal drug delivery ', Progress in Retinal and Eye Research, vol. 57, pp. 134-185 . https://doi.org/10.1016/j.preteyeres.2016.12.001 del Amo, E M, Rimpelä, A K, Heikkinen, E, Kari, O K, Ramsay, E, Lajunen, T, Schmitt, M, Pelkonen, L, Bhattacharya, M, Richardson, D, Subrizi, A, Turunen, T, Reinisalo, M, Itkonen, J, Toropainen, E, Casteleijn, M, Kidron, H, Antopolsky, M, Vellonen, K S, Ruponen, M & Urtti, A 2017, ' Pharmacokinetic aspects of retinal drug delivery ', Progress in Retinal and Eye Research, pp. 134-185 . https://doi.org/10.1016/j.preteyeres.2016.12.001 |
| Popis: | Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect the retina and choroid leading to impaired vision or blindness. Currently, intravitreal injections are the method of choice to administer drugs to the retina, but this approach is applicable only in selected cases (e.g. anti-VEGF antibodies and soluble receptors). There are two basic approaches that can be adopted to improve retinal drug delivery: prolonged and/or retina targeted delivery of intravitreal drugs and use of other routes of drug administration, such as periocular, suprachoroidal, sub-retinal, systemic, or topical. Properties of the administration route, drug and delivery system determine the efficacy and safety of these approaches. Pharmacokinetic and pharmacodynamic factors determine the required dosing rates and doses that are needed for drug action. In addition, tolerability factors limit the use of many materials in ocular drug delivery. This review article provides a critical discussion of retinal drug delivery, particularly from the pharmacokinetic point of view. This article does not include an extensive review of drug delivery technologies, because they have already been reviewed several times recently. Instead, we aim to provide a systematic and quantitative view on the pharmacokinetic factors in drug delivery to the posterior eye segment. This review is based on the literature and unpublished data from the authors' laboratory. published version peerReviewed |
| Databáze: | OpenAIRE |
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