A clustered plasticity model of long-term memory engrams

Autor:	Susumu Tonegawa, Arvind Govindarajan, Raymond J. Kelleher
Rok vydání:	2006
Předmět:	Neuronal Plasticity Synaptic scaling Long-term memory General Neuroscience Nonsynaptic plasticity Long-term potentiation Memory Metaplasticity Synaptic plasticity Animals Cluster Analysis Humans Neural Networks Computer Psychology Neuroscience Synaptic tagging Neuronal memory allocation
Zdroj:	Nature Reviews Neuroscience. 7:575-583
ISSN:	1471-0048 1471-003X
DOI:	10.1038/nrn1937
Popis:	Long-term memory and its putative synaptic correlates the late phases of both long-term potentiation and long-term depression require enhanced protein synthesis. On the basis of recent data on translation-dependent synaptic plasticity and on the supralinear effect of activation of nearby synapses on action potential generation, we propose a model for the formation of long-term memory engrams at the single neuron level. In this model, which we call clustered plasticity, local translational enhancement, along with synaptic tagging and capture, facilitates the formation of long-term memory engrams through bidirectional synaptic weight changes among synapses within a dendritic branch.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ced29449d12c97039331c8e87be378 https://doi.org/10.1038/nrn1937 Zobrazit plný text záznamu Plný text ve formátu PDF