Antioxidative assessment of new trans-palladium (II) complexes in head and neck cancer
| Autor: | Alicja Nowak-Zduńczyk, Katarzyna Malinowska, Dariusz Kaczmarczyk, Radosław Zajdel, Jurek Olszewski, Anna Merecz-Sadowska, Małgorzata Majczyk, Hanna Zielińska-Bliźniewska |
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| Přispěvatelé: | Zakład Alergologii i Rehabilitacji Oddechowej, II Katedra Otolaryngologii, Uniwersytet Medyczny w Łodzi, Katedra Otolaryngologii, Uniwersytet Medyczny w Łodzi, Katedra Informatyki Ekonomicznej, Uniwersytet Łódzki, Department of Otolaryngology, Laryngological Oncology, Audiology and Phoniatrics, USK WAM, Lodz, II Department of Otolaryngology, Medical University of Lodz, Poland, Zakład Fizjologii Człowieka, Uniwersytet Medyczny w Łodzi, Wyższa Szkoła Biznesu i Nauk o Zdrowiu w Łodzi |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Disease Pd (II) complexes Asymptomatic Antioxidants Pathogenesis antioxidant enzymes Internal medicine medicine Humans oxidative stress Aged Cisplatin reactive oxygen species Chemotherapy business.industry Squamous Cell Carcinoma of Head and Neck Superoxide Dismutase Head and neck cancer Cancer Middle Aged medicine.disease Catalase Otorhinolaryngology Fluorouracil Female head and neck cancer Poland medicine.symptom business Palladium medicine.drug |
| Popis: | Background: The head and neck neoplasms stand for 6% of all malignant neoplasms worldwide. The chemotherapy has limited use due to the tumor biological properties (in majority of cases moderately and poorly differentiated squamous cell carcinoma). The fundamental molecule used in the treatment is cisplatin and its derivates, that can be associated with fluorouracil. The new chemotherapeutic agents are not in common use during the treatment of head and neck malignancies. However, use of low molecular weight complexes Pd(II) have the potential to be more effective in therapy. Material and Methods: Fifty-one patients, 30 men and 21 women (aged 52.9 ± 12.1 years) with head and neck cancer were included in the study. Fifty-one healthy subjects, 31 men and 20 women, (aged 54.1 ± 14.7 years) years formed the control group. Antioxidant enzymes, superoxide dismutase, and catalase activities in erythrocytes were examined. Results: The increases level of antioxidant enzymes were seen in blood sample from patients with head and neck cancer after incubation with Pd(II) complex.. For that group we obtained statistically significant result p = |
| Databáze: | OpenAIRE |
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