Pharmacologic Interventions to Improve Splanchnic Oxygenation During Ventilation with Positive End-Expiratory Pressure
| Autor: | Fournell, A., Scheeren, T. W. L., Picker, O., Schwarte, L. A., Wolf, M, Bucher, HU, Rudin, M, VanHuffel, S, Wolf, U, Bruley, DF, Harrison, DK |
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| Přispěvatelé: | Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Vascular Ageing Programme (VAP) |
| Rok vydání: | 2011 |
| Předmět: |
Mechanical ventilation
Mean arterial pressure business.industry GASTRIC-MUCOSAL OXYGENATION medicine.medical_treatment Oxygenation INDUCED LUNG INJURY FENOLDOPAM DOPAMINE DOGS Respiratory failure Anesthesia Breathing SHOCK Medicine Continuous positive airway pressure ORGAN-FAILURE business Splanchnic PEEP Positive end-expiratory pressure circulatory and respiratory physiology |
| Zdroj: | Oxygen Transport to Tissue XXXIII ISBN: 9781461415657 OXYGEN TRANSPORT TO TISSUE XXXIII, 737, 235-238 |
| Popis: | Mechanical ventilation with positive end-expiratory pressure (PEEP) is an indispensable tool in the management of respiratory failure to preserve or improve lung function and systemic oxygenation. However, PEEP per se may also, as has been shown in experimental animals, impair regional microcirculation and oxygenation. The latter effects have received attention of late because of possible systemic sequelae such as multiple system organ failure (MSOF) in case of the splanchnic region. In this review, we examine the impact of pharmacologic interventions to improve splanchnic mucosal oxygen saturation depressed by mechanical ventilation with PEEP in a canine model of compromised cardiac function. Although much remains to be elucidated about the mechanisms of action, the primary way to improve splanchnic oxygenation seems to be a vasodilatory action of the drugs. |
| Databáze: | OpenAIRE |
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