A comparative study of the immunity region of lambdoid phages including Shiga-toxin-converting phages. Molecular basis for cross immunity
| Autor: | Yoshinobu Sugino, Satoshi Mizutani, Kazi Riaz Fattah, Farjana Jahan Fattah, Aizo Matsushiro |
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| Rok vydání: | 2000 |
| Předmět: |
Operator Regions
Genetic viruses Amino Acid Motifs Molecular Sequence Data Repressor Cross immunity Homology (biology) Shiga Toxin Immunity Genetics Base sequence Amino Acid Sequence Promoter Regions Genetic Molecular Biology Peptide sequence Base Sequence Models Genetic Sequence Homology Amino Acid biology Shiga toxin General Medicine Bacteriophage lambda Virology biology.protein Computer search |
| Zdroj: | Genes & Genetic Systems. 75:223-232 |
| ISSN: | 1880-5779 1341-7568 |
| DOI: | 10.1266/ggs.75.223 |
| Popis: | Comparison of eight lambdoid phages, including three Shiga-toxin converting phages, has been carried out with respect to the immunity region, especially the recognition helices of their repressor and CRO proteins on the one hand, and operator sequences on the other. Some as yet unassigned components of the regulatory circuits have been inferred by computer search. The cross immunity phenomenon shown by phages VT2-Sa and lambda is explained on the basis of similarity in their sequences. In addition, the similarity of 933W and HK022 in the sequences of their recognition helices of repressor and CRO, on the one hand, and operators, on the other, has led us to predict that they will have identical or similar immunity specificity. This homology has enabled us also to locate the OL (and consequently PL) of phage 933W that has been thought to be non-existent. |
| Databáze: | OpenAIRE |
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