Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms
| Autor: | Tamara Čačev, Monika Ulamec, Vanja Zjačić-Rotkvić, Sanja Kapitanović, Maja Cigrovski Berković, Davorka Herman Mahečić |
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| Jazyk: | chorvatština |
| Rok vydání: | 2020 |
| Předmět: |
Male
Interleukin-1beta Metastasis 0302 clinical medicine Tumor Microenvironment lcsh:R5-920 biology General Medicine Middle Aged Prognosis Immunohistochemistry Neuroendocrine Tumors IL-1β 030220 oncology & carcinogenesis Cytokines Tumor necrosis factor alpha Female medicine.symptom lcsh:Medicine (General) Research Article 030209 endocrinology & metabolism Inflammation Proinflammatory cytokine 03 medical and health sciences Immune system Stomach Neoplasms GEP-NEN Clinical Medical Sciences medicine Biomarkers Tumor inflammatory microenvironment TNF-α IL-6 IL-2 Humans Interleukin 6 Aged business.industry Interleukin-6 Tumor Necrosis Factor-alpha Basic Medical Sciences medicine.disease Pancreatic Neoplasms Ki-67 Antigen Tumor progression Cancer research biology.protein Interleukin-2 business Inflammatory microenvironment |
| Zdroj: | Bosnian journal of basic medical sciences Bosnian Journal of Basic Medical Sciences Bosnian Journal of Basic Medical Sciences (2020) |
| Popis: | Proinflammatory counterworks are important at different stages of tumor development, particularly during invasion and metastasis. Immune cells and their signal molecules can influence all stages of tumor progression, as well as therapeutic intervention. Proinflammatory cytokines are known triggers of growth in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). In this study, we explored the immunohistochemical expression of tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), IL-2, and IL-6 in tissues from 43 GEP-NEN patients with tumors of gastric, duodenal, ileal, appendical, and colonic origin. The immunohistochemical expression of TNF-α was increased in tumor groups with high proliferation rates (Ki67; p = 0.034), as well as in those with higher tumor grades (p = 0.05). Moreover, the immunohistochemical expression of TNF-α positively correlated with death outcomes (p = 0.016). Expression of IL-6, IL-1β, and IL-2 displayed similar immunohistochemical expression patterns regardless of Ki67, although the expression between the ILs differed. Most GEP-NENs had high levels of IL-6 and lower levels of IL-1β and IL-2. Although further comprehensive studies are required for a complete understanding of activated mechanisms in proinflammatory protumoral microenvironment of GEP-NENs, TNF-α is a potential marker in the prognosis of those tumors. |
| Databáze: | OpenAIRE |
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