Prediction of Newly Developed Acute Renal Failure using Serum Phosphorus Concentrations after Living-donor Liver Transplantation
| Autor: | Sang Hyun Hong, Chan-Suk Park, CO Park |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Graft dysfunction medicine.medical_specialty Biochemistry Gastroenterology Postoperative Complications Internal medicine Living Donors Humans Medicine Risk injury Retrospective Studies business.industry Biochemistry (medical) Phosphorus Retrospective cohort study Cell Biology General Medicine Acute Kidney Injury Middle Aged medicine.disease Liver Transplantation Surgery Postoperative mortality Female Serum phosphorus business Living donor liver transplantation Kidney disease |
| Zdroj: | Journal of International Medical Research. 40:2199-2212 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/030006051204000618 |
| Popis: | Objective: This retrospective study investigated the predictive role of serum phosphorus concentration for acute renal failure (ARF), defined by the Risk Injury Failure Loss End-stage kidney disease (RIFLE) criteria, after living-donor liver transplantation (LDLT). Methods: Perioperative factors, including serum phosphorus concentrations, in LDLT recipients without pre-existing renal dysfunction were retrospectively analysed and compared between patients with or without post-LDLT ARF. Results: A total of 45 patients out of 350 (12.9%) met the RIFLE ARF criteria and experienced significantly higher postoperative mortality, longer intensive care unit stay and more frequent graft dysfunction than those patients without post-LDLT ARF. Multivariate logistic regression analyses showed that a serum phosphorus concentration ≥ 4.5 mg/dl on postoperative day 1 (relative risk [RR] 5.31; 95% confidence interval [CI] 2.56, 11.03), a preoperative model for end-stage liver disease score = 20 points (RR 4.17, 95% CI 2.04, 8.52), and packed red blood cell transfusion ≥ 10 units (RR 2.55, 95% CI 1.13, 5.88) were independent risk factors for post-LDLT ARF. Conclusions: Hyper -phosphataemia on postoperative day 1 could be an early and simple indicator of ARF occurrence after LDLT. |
| Databáze: | OpenAIRE |
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