Chronic unilateral cervical vagotomy reduces renal inflammation, blood pressure, and renal injury in a mouse model of lupus
| Autor: | Caroline Gusson Shimoura, Grace Pham, Keisa W. Mathis, Sarika Chaudhari, D. V. Kulp |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Mean arterial pressure medicine.medical_specialty Physiology medicine.medical_treatment Lupus nephritis Blood Pressure Mice Inbred Strains Kidney Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine immune system diseases Internal medicine Albuminuria Animals Lupus Erythematosus Systemic Medicine skin and connective tissue diseases Cholinergic anti-inflammatory pathway Inflammation Nephritis Systemic lupus erythematosus business.industry Vagotomy medicine.disease Vagus nerve Disease Models Animal 030104 developmental biology Blood pressure Hypertension Cardiology Kidney Diseases business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Am J Physiol Renal Physiol |
| ISSN: | 1522-1466 1931-857X |
| Popis: | Systemic lupus erythematosus (SLE) is characterized by hypertension that results from chronic renal inflammation and dysautonomia in the form of dampened vagal tone. In health, the vagus nerve regulates inflammatory processes through mechanisms like the cholinergic anti-inflammatory pathway; so in the case of SLE, reduced efferent vagus nerve activity may indirectly affect renal inflammation and therefore hypertension. In this study, we sought to investigate the impact of disrupting vagal neurotransmission on renal inflammation and hypertension in the setting of chronic inflammatory disease. Female SLE ( NZBWF1) and control ( NZW) mice were subjected to a right unilateral cervical vagotomy or sham surgery and 3 wk later were implanted with indwelling catheters to measure blood pressure. Indices of splenic and renal inflammation, as well as renal injury, were assessed. Unilateral vagotomy blunted SLE-induced increases in mean arterial pressure, albumin excretion rate, and glomerulosclerosis. This protection was associated with reduced splenic T cells and attenuated SLE-induced increases in renal proinflammatory mediators. In summary, these data indicate that unilateral vagotomy reduces renal inflammation and reduces blood pressure in SLE mice. The vagus nerves have myriad functions, and perhaps other neuroimmune interactions compensate for the ligation of one nerve. |
| Databáze: | OpenAIRE |
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