A case of hepatosplenic T-cell lymphoma successfully treated by HLA haploidentical stem cell transplantation

Autor: Yoshinobu Maeda, Toshiro Kurokawa, Noriko Iwaki, Kanako Mochizuki, Jun Ozaki
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Melphalan
Male
medicine.medical_specialty
Hepatosplenic T-cell lymphoma
Prednisolone
Graft vs Host Disease
Case Report
Lymphoma
T-Cell
Gastroenterology
Tacrolimus
03 medical and health sciences
0302 clinical medicine
HLA Antigens
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Cyclophosphamide
graft-versus-host disease (GVHD)
Neutrophil Engraftment
business.industry
Splenic Neoplasms
Liver Neoplasms
Hematopoietic Stem Cell Transplantation
General Medicine
Middle Aged
medicine.disease
hepatosplenic T-cell lymphoma (HSTL)
Lymphoma
Transplantation
030104 developmental biology
medicine.anatomical_structure
surgical procedures
operative
Methotrexate
Treatment Outcome
Doxorubicin
Vincristine
030220 oncology & carcinogenesis
Transplantation
Haploidentical
haploidentical stem cell transplantation
Bone marrow
business
Busulfan
Immunosuppressive Agents
medicine.drug
Zdroj: Journal of Clinical and Experimental Hematopathology : JCEH
ISSN: 1880-9952
1346-4280
Popis: We report a case of hepatosplenic T-cell lymphoma (HSTL) transplanted from an HLA-haploidentical daughter. A 51-year-old man was referred due to liver function test abnormalities and fever. He was confirmed to have γδ-type HSTL by bone marrow and liver biopsies. He was treated with five cycles of a CHOP regimen. Although metabolic complete response (CR), as defined by positron emission tomography, was achieved, his bone marrow still contained tumor cells on polymerase chain reaction (PCR). He underwent transplantation using unmanipulated peripheral blood stem cells from his HLA-haploidentical daughter. The preconditioning regimen consisted of fludarabine, melphalan, busulfan and antithymocyte globulin. Graft-versus-host disease (GVHD) prophylaxis consisted of tacrolimus and short-term methotrexate. Neutrophil engraftment was achieved on day 14. His bone marrow exhibited a completely female phenotype by fluorescence in situ hybridization, and no lymphoma cells were detected by PCR on day 30. Although he developed grade II acute GVHD on day 47, it was successfully treated by prednisolone. He has a limited type of skin chronic GVHD and still receives oral immunosuppressive therapy. He remains in CR four years after transplantation.
Databáze: OpenAIRE
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