Validation of 3D volumetric-based renal function prediction calculator for nephron sparing surgery

Autor: Jonathan A. Coleman, Aashish Kabra, Hugh White, Stephanie Nougaret, Jaime Landman, Renato B. Corradi, Melissa Suarez, Hebert Alberto Vargas, Michael A. Liss, Jacob Oppenheimer, Zhamshid Okhunov
Přispěvatelé: Memorial Sloane Kettering Cancer Center [New York], University of Texas Health Science Center, The University of Texas Health Science Center at Houston (UTHealth), University of California [Irvine] (UCI), University of California, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Rok vydání: 2017
Předmět:
Male
Nephrology
medicine.medical_treatment
030232 urology & nephrology
Kidney
urologic and male genital diseases
Nephrectomy
0302 clinical medicine
Chronic kidney disease
Partial nephrectomy
Postoperative Period
Middle Aged
Kidney Neoplasms
female genital diseases and pregnancy complications
Tumor Burden
3. Good health
Renal cancer
030220 oncology & carcinogenesis
Preoperative Period
symbols
Female
Nephron sparing surgery
Glomerular Filtration Rate
medicine.medical_specialty
Urology
Clinical Decision-Making
MESH: Carcinoma
Renal Cell/diagnostic imaging
Kidney/physiopathology
Kidney Neoplasms/surgery
Renal function
[SDV.CAN]Life Sciences [q-bio]/Cancer
Article
Retrospective data
03 medical and health sciences
symbols.namesake
Imaging
Three-Dimensional
Predictive Value of Tests
Internal medicine
Multidetector Computed Tomography
medicine
Renal mass
Humans
Calculator
Carcinoma
Renal Cell
Aged
Retrospective Studies
Internet
business.industry
Nephrons
Pearson product-moment correlation coefficient
Surgery
business
Organ Sparing Treatments
Software
Student's t-test
Zdroj: International Urology and Nephrology
International Urology and Nephrology, Springer Verlag, 2017, 49 (4), pp.615-621. ⟨10.1007/s11255-017-1525-y⟩
ISSN: 1573-2584
0301-1623
DOI: 10.1007/s11255-017-1525-y
Popis: International audience; OBJECTIVE:To evaluate a recently published volume-based renal function prediction calculator intended to be used in small renal mass surgical counseling.METHODS:Retrospective data collection included three-dimensional calculation of renal mass and parenchyma of patients who have undergone extirpative therapy. The predicted glomerular filtration rate (GFR) was calculated using the online calculator. The predicted GFR was compared with the actual 6-month GFR. The Pearson correlation coefficient, paired t test and root-mean-square error (RMSE) are utilized for statistical analysis.RESULTS:After institutional review board approval, three institutions provided data for analysis. After patients with renal mass size >300 cc, renal size >400 cc or preoperative CKD ≥stage 3 had been excluded, we retrospectively analyzed data from 136 patients. The median mass volume was 22.2 cc (IQR 7-49). In multiple linear regression analysis, the most significant variables predicting postoperative GFR were partial versus radical nephrectomy and preoperative GFR with an overall R2 of .68 (F = 26.13, P < .001). The predicted GFR was 75.4 mL/min/1.73 m2 compared to an actual GFR of 70.7 mL/min/1.73 m2 (P < .001, paired t test). The predicted GFR was highly correlated with the actual postoperative GFR at 6 months (Pearson correlation, r = .65, P < .001). RMSE of the validation cohort was 16.87.CONCLUSIONS:The predictive tool to determine renal function benefit of nephron sparing surgery compared to radical nephrectomy online calculator effectively predicts GFR and could potentially be used to help urologists and patients discuss renal function prior to extirpative renal surgery.
Databáze: OpenAIRE
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