Highly Porous, Water-Soluble, Superparamagnetic, and Biocompatible Magnetite Nanocrystal Clusters for Targeted Drug Delivery
| Autor: | Sun-Hee Kim, Wanping Guo, Chang-Sik Ha, Jae-Ho Bae, Fuping Dong |
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| Rok vydání: | 2011 |
| Předmět: |
Biocompatibility
Cell Survival Chemistry Organic Chemistry Water Ibuprofen Nanotechnology General Chemistry Ferrosoferric Oxide Catalysis chemistry.chemical_compound Drug Delivery Systems Solubility Chemical engineering Nanocrystal Targeted drug delivery Drug delivery Humans Magnetic nanoparticles Surface modification Female Porosity Magnetite Trisodium citrate |
| Zdroj: | Chemistry - A European Journal. 17:12802-12808 |
| ISSN: | 0947-6539 |
| DOI: | 10.1002/chem.201101110 |
| Popis: | Magnetic particles have become very promising materials for drug delivery. However, preparation of magnetite particles with high surface area, biocompatibility, strong magnetic response, and suitable particle size still remains a major challenge. In this report, magnetite nanocrystal clusters with high surface areas were fabricated through a solvothermal process by introducing ammonium acetate as a porogen and trisodium citrate as a surface modification agent. The porosity, which was controlled by the reactant concentration, has been investigated in detail. The surface area of the nanocrystal clusters was as high as 141 m(2) g(-1). Ibuprofen, as a model drug, was entrapped into the magnetite carriers. The interfacial interaction between the carboxylic groups on the drug molecules and the carboxylate groups on the carriers enhanced the loading efficiency. Low cytotoxicity in MCF-7 cell and in vitro constant drug release behavior combined with the high drug loading efficiency and high saturation magnetization values demonstrated the potential of the as-synthesized magnetite materials in targeted drug release systems. |
| Databáze: | OpenAIRE |
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