HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil
| Autor: | Fabiana Granja, André de Lima Guerra Corado, Renato Augusto Carvalho Leão, Felipe Gomes Naveca, Gonzalo Bello |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
RNA viruses Male Epidemiology lcsh:Medicine HIV Infections Drug resistance medicine.disease_cause Pathology and Laboratory Medicine Geographical locations Database and Informatics Methods 0302 clinical medicine Immunodeficiency Viruses Medicine and Health Sciences Public and Occupational Health 030212 general & internal medicine lcsh:Science Clade Phylogeny Mutation Multidisciplinary Antimicrobials virus diseases Drugs Antiretrovirals Viral Load Middle Aged Antivirals Vaccination and Immunization Medical Microbiology HIV epidemiology Viral Pathogens Viruses Population study Female Pathogens Viral load Sequence Analysis Brazil Research Article Adult Bioinformatics Anti-HIV Agents Immunology Antiretroviral Therapy Biology Research and Analysis Methods Microbiology 03 medical and health sciences Young Adult Acquired immunodeficiency syndrome (AIDS) Antiviral Therapy Virology Microbial Control Retroviruses Drug Resistance Viral medicine Humans Microbial Pathogens Aged Pharmacology Genetic diversity lcsh:R Lentivirus Organisms Biology and Life Sciences HIV South America medicine.disease Reverse transcriptase 030104 developmental biology HIV-1 lcsh:Q Antimicrobial Resistance Preventive Medicine People and places Viral Transmission and Infection |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 3, p e0173894 (2017) |
| ISSN: | 1932-6203 |
| Popis: | The HIV-1 epidemic in Brazil has spread towards the Northern country region, but little is known about HIV-1 subtypes and prevalence of HIV strains with resistance mutations to antiretrovirals in some of the Northern states. HIV-1 protease (PR) and reverse transcriptase (RT) sequences were obtained from 73 treatment-naive and -experienced subjects followed between 2013 and 2014 at a public health reference unit from Roraima, the northernmost Brazilian state. The most prevalent HIV-1 clade observed in the study population was the subtype B (91%), followed by subtype C (9%). Among 12 HIV-1 strains from treatment-naïve patients, only one had a transmitted drug resistance mutation for NNRTI. Among 59 treatment-experienced patients, 12 (20%) harbored HIV-1 strains with acquired drug resistance mutations (ADRM) that reduce the susceptibility to two classes of antiretroviral drugs (NRTI and NNRTI or NRTI and PI), and five (8%) harbored HIV-1 strains with ADRM that reduced susceptibility to only one class of antiretroviral drugs (NNRTI or PI). No patients harboring HIV strains with reduced susceptibility to all three classes of antiretroviral drugs were detected. A substantial fraction of treatment-experienced patients with (63%) and without (70%) ADRM had undetectable plasma viral loads ( |
| Databáze: | OpenAIRE |
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