EMT Transition States during Tumor Progression and Metastasis
| Autor: | Cédric Blanpain, Ievgenia Pastushenko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Epithelial-Mesenchymal Transition
Gene regulatory network Tumor initiation Biology epithelial–mesenchymal transition Metastasis 03 medical and health sciences stemness 0302 clinical medicine Neoplasms medicine Animals Humans cancer metastasis Epithelial–mesenchymal transition Epigenetics Neoplasm Metastasis Cell Proliferation 030304 developmental biology 0303 health sciences Mesenchymal stem cell Cancer Cell Biology medicine.disease hybrid EMT Tumor progression plasticity embryonic structures Disease Progression Cancer research Biologie cellulaire 030217 neurology & neurosurgery |
| Zdroj: | Trends in cell biology, 29 (3 |
| Popis: | Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells acquire mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion, metastasis, and resistance to therapy. Recently, it has been demonstrated that EMT is not a binary process, but occurs through distinct cellular states. Here, we review the recent studies that demonstrate the existence of these different EMT states in cancer and the mechanisms regulating their functions. We discuss the different functional characteristics, such as proliferation, propagation, plasticity, invasion, and metastasis associated with the distinct EMT states. We summarize the role of the transcriptional and epigenetic landscapes, gene regulatory network and their surrounding niche in controlling the transition through the different EMT states. SCOPUS: re.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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