High basal heat-shock protein expression in bats confers resistance to cellular heat/oxidative stress
| Autor: | Yok Teng Chionh, Aaron T. Irving, Javier Koh, Koji Itahana, Jie Cui, Lin-Fa Wang, Justin H. J. Ng, Dolyce H. W. Low, Ian H. Mendenhall |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
media_common.quotation_subject Longevity medicine.disease_cause Biochemistry Cell Line 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Heat shock protein Chiroptera medicine Animals Humans HSP70 Heat-Shock Proteins HSP90 Heat-Shock Proteins media_common Original Paper biology Metabolism Cell Biology Hsp90 Adaptation Physiological Hsp70 Cell biology Oxidative Stress 030104 developmental biology Cell culture Flight Animal biology.protein 030217 neurology & neurosurgery Oxidative stress Heat-Shock Response |
| Zdroj: | Cell Stress and Chaperones |
| ISSN: | 1466-1268 1355-8145 |
| DOI: | 10.1007/s12192-019-01013-y |
| Popis: | Bats, unique among mammals with powered flight, have many species with the longest size-proportionate lifespan of all mammals. Evolutionary adaptations would have been required to survive the elevated body temperatures during flight. Heat shock protein (HSP), highly conserved master regulators of cell stress, expression was examined across tissues and various cell lines in bats. Basal expression level of major HSPs (HSP70 and HSP90) is significantly higher in two different bat species compared to other mammals. This HSP expression could be a bat-unique, key factor to modulate cellular stress and death. Consequently, bat cells survive prolonged heat treatment, along with other stress stimuli, in a HSP-dependent manner, whereas other mammalian cells succumbed. This suggests HSP expression in bats could be an important adaption to intrinsic metabolic stresses like flight and therefore an important model to study stress resilience and longevity in general. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12192-019-01013-y) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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