High flow nasal heliox improves work of breathing and attenuates lung injury in a newborn porcine lung injury model
| Autor: | Jordan V Wang, Yan Zhu, Marla R. Wolfson, Elena Rodriguez, T.H. Shaffer, Haritha Vellanki, R.K. Jassar, Anne M. Hesek |
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| Rok vydání: | 2016 |
| Předmět: |
Swine
Acute Lung Injury Lung injury medicine.disease_cause Heliox Helium Work of breathing medicine Animals Work of Breathing Lung Respiratory distress business.industry Interleukin-6 Pulmonary Gas Exchange Interleukin-8 Oxygen Inhalation Therapy Pneumonia respiratory system Oxygen Disease Models Animal medicine.anatomical_structure Anesthesia Pediatrics Perinatology and Child Health Medical gas therapy Breathing business Pulmonary Ventilation Nasal cannula |
| Zdroj: | Journal of neonatal-perinatal medicine. 8(4) |
| ISSN: | 1878-4429 |
| Popis: | Background High flow nasal cannula (HFNC) has been shown to improve ventilation and oxygenation and reduce work of breathing in newborns with respiratory distress. Heliox, decreases resistance to airflow, reduces the work of breathing, facilitates the distribution of inspired gas, and has been shown to attenuate lung inflammation during the treatment of acute lung injury. Hypothesis Heliox delivered by HFNC will decrease resistive load, decrease work of breathing, improve ventilation and attenuate lung inflammation during spontaneous breathing following acute lung injury in the newborn pig. Methods Spontaneously breathing neonatal pigs received Nitrox or Heliox by HFNC and studied over 4 hrs following oleic acid injury. Gas exchange, pulmonary mechanics and systemic inflammation were measured serially. Lung inflammation biomarkers were assessed at termination. Results Heliox breathing animals demonstrated lower work of breathing reflected by lower tracheal pressure, phase angle and phase relationship. Ventilation efficiency index was greater compared to Nitrox. Heliox group showed less lung inflammation reflected by lower tissue interleukin-6 and 8. Conclusion High flow nasal Heliox decreased respiratory load, reduced resistive work of breathing indices and attenuated lung inflammatory profile while ventilation was supported at less pressure effort in the presence of acute lung injury. |
| Databáze: | OpenAIRE |
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