Association between cardiorespiratory fitness, obesity, and incidence of atrial fibrillation☆

Autor: Khin Chan, Peter Kokkinos, Christina Grüne de Souza e Silva, Shirit Kamil-Rosenberg, Jonathan Myers, Win Leth Shwe Yee, Joshua Abella
Jazyk: angličtina
Rok vydání: 2020
Předmět:
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
HTN
Hypertension
PA
Physical activity
CRF
Cardiorespiratory fitness
BMI
Body mass index
030204 cardiovascular system & hematology
Overweight
Arrhythmias
MET
Metabolic equivalent
Metabolic equivalent
HR
Hazard ratio
03 medical and health sciences
Cardiopulmonary fitness
BMI
0302 clinical medicine
CVD
Cardiovascular disease
Internal medicine
medicine
AF
Atrial fibrillation
030212 general & internal medicine
VA
Veterans affairs
Original Paper
business.industry
Incidence (epidemiology)
Cardiorespiratory fitness
DM
Diabetes mellitus
medicine.disease
Obesity
Quartile
Risk factors
lcsh:RC666-701
Cohort
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Body mass index
CPRS
Computerized patient record system
ETT
Exercise tolerance test
Zdroj: International Journal of Cardiology. Heart & Vasculature
International Journal of Cardiology: Heart & Vasculature, Vol 31, Iss, Pp 100663-(2020)
ISSN: 2352-9067
Popis: Background: The interaction between cardiorespiratory fitness (CRF) and incidence of atrial fibrillation (AF) and the interaction between obesity and incidence of AF have been explored separately. Therefore, we evaluated the association between CRF, body mass index (BMI), and risk of developing AF in a cohort of middle-aged and older US Veterans. Methods: Symptom limited exercise tests (ETT) were conducted among 16,397 Veterans (97% male) from January 9,1987 to December 31,2017. No history of AF was evident at the time of the ETTs. CRF was expressed as quartiles of peak metabolic equivalents (METs) achieved within each age decile. Weight status was classified as normal (BMI 35 kg/m2). Multivariable Cox proportional hazards regression models were used to compare the association between BMI, CRF categories, and incidence of AF. Results: Over a median follow-up of 10.7 years, 2,155 (13.1%) developed AF. Obese and severely obese subjects had 13% and 32% higher risks for incidence of AF, respectively, vs. normal weight subjects. Overweight and obese subjects in the most fit quartile had 50% decline in AF risk compared to the least-fit subjects. Severely obese subjects had marked increases in AF risk (~50–60%) regardless of fitness level. Risk of developing AF increases with higher BMI and lower CRF. Conclusion: Improving CRF should be advocated when assessing those at risk for developing AF.
Databáze: OpenAIRE
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