The Potential of CAR T Cell Therapy in Pancreatic Cancer

Autor: Mehmet Akce, Mohammad Y. Zaidi, Edmund K. Waller, Bassel F. El-Rayes, Gregory B. Lesinski
Rok vydání: 2018
Předmět:
lcsh:Immunologic diseases. Allergy
0301 basic medicine
Oncology
medicine.medical_specialty
T cell
medicine.medical_treatment
Immunology
adoptive T cell therapy
Epitopes
T-Lymphocyte
genetically engineered T cells
Review
Protein Engineering
Immunotherapy
Adoptive
Cell therapy
03 medical and health sciences
0302 clinical medicine
Clinical Trials
Phase II as Topic
Antigen
pancreas cancer
Internal medicine
Pancreatic cancer
medicine
Tumor Microenvironment
Immunology and Allergy
Cytotoxic T cell
Animals
Humans
CAR T cells
Receptors
Chimeric Antigen
Clinical Trials
Phase I as Topic
business.industry
Cancer
Immunotherapy
mesothelin
medicine.disease
Combined Modality Therapy
Chimeric antigen receptor
3. Good health
Pancreatic Neoplasms
Disease Models
Animal
030104 developmental biology
medicine.anatomical_structure
Treatment Outcome
030220 oncology & carcinogenesis
lcsh:RC581-607
business
Zdroj: Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
ISSN: 1664-3224
Popis: Pancreatic cancer has a dismal prognosis and effective treatment options are limited. It is projected to be the second most common cause of cancer related mortality in the United States by 2030 and there is urgent unmet need for novel systemic treatment options. Immunotherapy with antibodies targeting PD-1, PD-L1, CTLA-4 has not shown clinical activity in unselected pancreatic cancer, emphasizing the need for combination immunotherapy approaches or other therapeutic strategies. As such, chimeric antigen receptor (CAR) T cell therapy represents an emerging therapeutic option for pancreatic cancer. This modality utilizes genetically engineered T cells that are redirected to specific cancer-associated antigens to elicit potent cytotoxic activity. This review summarizes the available preclinical data and highlights early phase clinical trials using CAR T cell approaches in pancreatic cancer, a disease state that is gaining attention as a conduit for cell therapy. Future directions in application of CAR T cell therapy are also considered including its ability to be directed against novel epitopes and combined with other therapeutic regimens.
Databáze: OpenAIRE
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