Regulation of hyaluronan synthases in mouse uterine cervix
Autor: | Taro Uchiyama, Tomohiro Sakuta, Toshiji Kanayama |
---|---|
Rok vydání: | 2004 |
Předmět: |
Keratinocytes
Serum Glucuronosyltransferase Biophysics Inflammation Cervix Uteri Biology Biochemistry Gene Expression Regulation Enzymologic Andrology chemistry.chemical_compound Mice Pregnancy Transferases medicine Animals RNA Messenger Hyaluronic Acid Molecular Biology Progesterone Regulation of gene expression Messenger RNA Base Sequence RNA Cell Biology Fibroblasts medicine.disease Molecular Weight Hyaluronan synthase chemistry Immunology biology.protein Female Keratinocyte growth factor medicine.symptom Hyaluronan Synthases Interleukin-1 |
Zdroj: | Biochemical and biophysical research communications. 327(3) |
ISSN: | 0006-291X |
Popis: | We examined the expression pattern of hyaluronan synthase (HAS) mRNAs in the uterine cervix of pregnant mice. The expression levels of HAS-1 and -2 mRNAs peaked at delivery, whereas that of HAS-3 mRNA peaked on the 15th day of pregnancy. The regulation of HAS mRNA expression was examined in pregnant mouse uterine cervical fibroblasts. The expression of HAS-1, -2, and -3 mRNAs was significantly augmented by interleukin-1beta (IL-1beta). Progesterone significantly interfered with expression of HAS-1 and -2 mRNAs, but significantly increased the expression of HAS-3 mRNA. Low-molecular-weight hyaluronan significantly enhanced only the expression of HAS-1 mRNA. These results indicate that HAS in the uterine cervix is regulated in a complex manner by IL-1beta, progesterone, and low-molecular-weight hyaluronan, of which changes in the cervical tissue and serum closely participate in uterine cervical ripening and/or inflammation. |
Databáze: | OpenAIRE |
Externí odkaz: |