Dietary Supplementation with a Low Dose of Polyphenol-Rich Grape Pomace Extract Prevents Dextran Sulfate Sodium-Induced Colitis in Rats
| Autor: | Didier Fraisse, Bruno Pereira, Catherine Felgines, Marie-Paule Vasson, Ahlem Boussenna, Juliette Joubert-Zakeyh, Odile Texier |
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| Přispěvatelé: | Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), 3inature Biosphère, Anatomie et cytologie pathologiques, CHU Clermont-Ferrand, Délégation à la Recherche Clinique et à l'Innovation (DRCI), 3inature Biosphere, Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Clermont-Ferrand |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine 040301 veterinary sciences Anti-Inflammatory Agents Medicine (miscellaneous) Inflammatory bowel disease Antioxidants aliment enrichi 0403 veterinary science 03 medical and health sciences polyphénol medicine Animals grape pomace extract Vitis Dietary supplementation rat Food science Rats Wistar Colitis Dextran Sulfate Sodium Acute colitis polyphenols Peroxidase marc de raisin 030109 nutrition & dietetics Nutrition and Dietetics colon Plant Extracts Superoxide Dismutase Chemistry Dextran Sulfate Low dose fungi Pomace food and beverages 04 agricultural and veterinary sciences Inflammatory Bowel Diseases medicine.disease maladie inflammatoire intestinale 3. Good health Polyphenol inflammation Fruit Dietary Supplements [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Phytotherapy rôle protecteur |
| Zdroj: | Journal of Medicinal Food Journal of Medicinal Food, Mary Ann Liebert, 2016, 19 (8), pp.755-758. ⟨10.1089/jmf.2015.0124⟩ Journal of Medicinal Food, 2016, 19 (8), pp.755-758. ⟨10.1089/jmf.2015.0124⟩ |
| ISSN: | 1096-620X |
| DOI: | 10.1089/jmf.2015.0124⟩ |
| Popis: | Evidence from several epidemiological and experimental studies points to a beneficial role of dietary polyphenols in inflammatory bowel disease. In this study, we investigate the protective effect of dietary supplementation with various amounts of a polyphenol-rich grape pomace extract (GPE) on the development of dextran sulfate sodium (DSS)-induced colitis in rats. Rats were fed 21 days on a semisynthetic diet enriched with GPE (0.1%, 0.5%, and 1%), and acute colitis was induced by DSS (40 g/L in the drinking water) administration during the last 7 days. The low GPE content in the diet (0.1%) attenuated clinical signs and colon shortening and limited DSS-induced histological lesions. GPE 0.1% also attenuated the DSS-induced increase in myeloperoxidase activity and improved superoxide dismutase activity. Higher amounts of GPE in the diet induced only weak and nonsignificant protective effects. These results suggest that consumption of a low amount of polyphenol-rich GPE helps protect against colitis development. |
| Databáze: | OpenAIRE |
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