Nicotinamide Adenine Dinucleotide-Dependent Retinoic Acid Formation From Retinol in the Human Gastric Mucosa: Inhibition by Ethanol, Acetaldehyde, and H2 Blockers
| Autor: | Michiko Miyagi, Shinzo Kato, Michinaga Matsumoto, Hirokazu Yokoyama, Hiromasa Ishii, Haruko Shiraishi |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
medicine.medical_specialty Retinoic acid Medicine (miscellaneous) Tretinoin Acetaldehyde Nicotinamide adenine dinucleotide Ranitidine Toxicology chemistry.chemical_compound Internal medicine medicine Gastric mucosa Humans Vitamin A Alcohol dehydrogenase Ethanol biology Retinol Middle Aged NAD Psychiatry and Mental health Endocrinology medicine.anatomical_structure Histamine H2 Antagonists chemistry Gastric Mucosa biology.protein NAD+ kinase Cimetidine |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 25:24S-28S |
| ISSN: | 1530-0277 0145-6008 |
| DOI: | 10.1111/j.1530-0277.2001.tb02413.x |
| Popis: | All-trans retinoic acid formation from all-trans retinol (vitamin A) in the human gastric mucosa was studied. When all-trans retinol and the human gastric mucosa were incubated together, all-trans retinoic acid was formed in the presence of nicotinamide adenine dinucleotide (NAD). When the NAD was not added, hardly any formation was observed. The formation of all-trans retinoic acid tended to be attenuated by 10 mM ethanol. Moreover, it was significantly attenuated in a concentration-dependent manner by ethanol at concentrations of 100 mM and above. Acetaldehyde at concentrations of 50 microM and above also significantly attenuated its formation in a concentration-dependent manner. Some H2 blockers, which include ranitidine hydrochloride and cimetidine, significantly attenuated the formation of all-trans retinoic acid, whereas famotidine failed to suppress it. There is an NAD-dependent pathway by which all-trans retinoic acid is produced from all-trans retinol in the human gastric mucosa. Inhibitors of alcohol dehydrogenase, which include ethanol and some H2 blockers, and of aldehyde dehydrogenase, which include acetaldehyde, inhibit its production. |
| Databáze: | OpenAIRE |
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