Optimised rapeseed oil optimises oxidative stress and lipid profile
| Autor: | Sonchita R. Mudi, Subrata K. Biswas |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Food Handling Inflammation medicine.disease_cause Pathogenesis Fatty Acids Monounsaturated chemistry.chemical_compound Internal medicine Diabetes mellitus medicine Animals Plant Oils medicine.diagnostic_test Cholesterol business.industry medicine.disease Atherosclerosis Lipids Oxidative Stress Endocrinology chemistry Rapeseed Oil Animal studies medicine.symptom Cardiology and Cardiovascular Medicine Lipid profile business Dyslipidemia Oxidative stress |
| Zdroj: | Atherosclerosis. 213(2) |
| ISSN: | 1879-1484 |
| Popis: | Despite extensive research throughout the 20th century, cardioascular disease (CVD) is still the leading cause of deathworldwide. therosclerosis is the most important contributor to and underying mechanism for CVD. Atherosclerosis is a slowly progressive isease characterized by the accumulation of lipids and fibrous issue in the intimal layer of arteries. The involvement of blood ipids, particularly hypercholesterolemia, in the pathogenesis of therosclerosis has been confirmed in animal studies and clinical rials with lipid lowering agents. In fact, it has been demonstrated hat each 40mg per deciliter reduction in LDL cholesterol correponds to a 24% reduction of major cardiovascular events [1], and ach 1mg per deciliter increase in HDL-cholesterol is associated ith a 2–3% reduction in the risk of future coronary heart disease 2]. Recent research, however, indicates the direct involvement of nflammationandoxidative stress for the initiationandprogression f atherosclerosis [3,4]. The process of atherosclerosis involves complex interactions mong the genetic and environmental factors. Many of the isk factors for atherosclerosis and CVD including dyslipidemia, ypertension, obesity, diabetes mellitus, smoking, hyperhomoysteinemia and sedentary life style can induce endothelial cell ysfunction, oneof theearly events in atherosclerosis.Normally the ndothelium resists prolonged contact with circulating leukocytes. owever, following endothelial cell dysfunction or inflammatory |
| Databáze: | OpenAIRE |
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