Disentangling the role of corticobasal ganglia loops in top-down and bottom-up vsual attention: an investigation of attention deficits in Parkinson's disease
| Autor: | Laura Bertolasi, Mirta Fiorio, Paul Krack, Jérôme Yelnik, Giuseppe Ricciardi, Valérie Fraix, Jan Theeuwes, Pierre Pollak, Francesca Sala, Giorgio Tommasi, Antonio Fiaschi, Leonardo Chelazzi, Jean-François Le Bas, Emmanuelle Schmitt |
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| Přispěvatelé: | Cognitive Psychology |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Parkinson's disease Deep Brain Stimulation Cognitive Neuroscience visual attention attentional capture top-down control of attention bottom-up control of attention visual search basal ganglia Poison control Disease Motor Activity Neuropsychological Tests Developmental psychology Task (project management) Cohort Studies Basal ganglia Reaction Time medicine Humans Visual Pathways/physiopathology Attention Visual Pathways Attention/*physiology Set (psychology) Cerebral Cortex Visual search Computers Basal Ganglia/*physiopathology Parkinson Disease/drug therapy/*physiopathology/*psychology/surgery Parkinson Disease Motor Activity/physiology Cognition Middle Aged medicine.disease ddc:616.8 Visual Perception/*physiology Visual Perception Cerebral Cortex/*physiopathology Female Psychology Neuroscience |
| Zdroj: | Tommasi, G, Fiorio, M, Yelnik, J, Krack, P, Sala, F, Schmitt, E, Fraix, V, Bertolasi, L, Le Bas, J F, Ricciardi, G, Fiaschi, A, Theeuwes, J, Pollak, P & Chelazzi, L 2015, ' Disentangling the Role of Cortico-Basal Ganglia Loops in Top–Down and Bottom–Up Visual Attention: An Investigation of Attention Deficits in Parkinson Disease ', Journal of Cognitive Neuroscience, vol. 27, no. 6, pp. 1215-1237 . https://doi.org/10.1162/jocn_a_00770 Journal of Cognitive Neuroscience, Vol. 27, No 6 (2015) pp. 1215-1237 Journal of Cognitive Neuroscience, 27(6), 1215-1237. MIT Press Journals |
| ISSN: | 0898-929X |
| Popis: | It is solidly established that top–down (goal-driven) and bottom–up (stimulus-driven) attention mechanisms depend on distributed cortical networks, including prefrontal and frontoparietal regions. On the other hand, it is less clear whether the BG also contribute to one or the other of these mechanisms, or to both. The current study was principally undertaken to clarify this issue. Parkinson disease (PD), a neurodegenerative disorder primarily affecting the BG, has proven to be an effective model for investigating the contribution of the BG to different brain functions; therefore, we set out to investigate deficits of top–down and bottom–up attention in a selected cohort of PD patients. With this objective in mind, we compared the performance on three computerized tasks of two groups of 12 parkinsonian patients (assessed without any treatment), one otherwise pharmacologically treated and the other also surgically treated, with that of a group of controls. The main behavioral tool for our study was an attentional capture task, which enabled us to tap the competition between top–down and bottom–up mechanisms of visual attention. This task was suitably combined with a choice RT and a simple RT task to isolate any specific deficit of attention from deficits in motor response selection and initiation. In the two groups of patients, we found an equivalent increase of attentional capture but also comparable delays in target selection in the absence of any salient distractor (reflecting impaired top–down mechanisms) and movement initiation compared with controls. In contrast, motor response selection processes appeared to be prolonged only in the operated patients. Our results confirm that the BG are involved in both motor and cognitive domains. Specifically, damage to the BG, as it occurs in PD, leads to a distinct deficit of top–down control of visual attention, and this can account, albeit indirectly, for the enhancement of attentional capture, reflecting weakened ability of top–down mechanisms to antagonize bottom–up control. |
| Databáze: | OpenAIRE |
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