Fractionated stereotactic radiosurgery for malignant gliomas: comparison with single session stereotactic radiosurgery
| Autor: | Jung-Il Lee, Kyung Rae Cho, Jung Won Choi, Ho Jun Seol, Doo-Sik Kong, Seung Won Choi, Do-Hyun Nam |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_treatment Planning target volume Radiosurgery Effective dose (radiation) 03 medical and health sciences 0302 clinical medicine Glioma medicine Humans Clinical efficacy Radiation Injuries Aged Retrospective Studies Brain Neoplasms business.industry food and beverages Middle Aged medicine.disease Progression-Free Survival Radiation necrosis Exact test Neurology Oncology 030220 oncology & carcinogenesis Female Dose Fractionation Radiation Neurology (clinical) business Nuclear medicine Single session 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuro-Oncology. 145:571-579 |
| ISSN: | 1573-7373 0167-594X |
| Popis: | Stereotactic radiosurgery (SRS) is feasible for malignant glioma; however, delivering the optimal radiation dose with sufficient large-volume coverage is a major concern. We aimed to investigate the clinical efficacy and safety of fractionated SRS (fSRS) versus single-session SRS (sSRS) for malignant gliomas. We retrospectively reviewed 58 malignant glioma patients who underwent gamma knife SRS from January 2015 to December 2018. Forty-one underwent sSRS, and 17 underwent fSRS. Median dose for fSRS was 28 Gy (range 24–35 Gy), with a median dose of 6 Gy per fraction (range 5–7 Gy). Patients received 4 or 5 fractions on consecutive days. Median dose for sSRS was 18 Gy (range 11–25 Gy), with a median isodose of 50% (range 50–65%). Mean target volumes were 5.9 and 19.3 cc for sSRS and fSRS, respectively (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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